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Title: Integrity of Multiple Memory Systems in Individuals With Untreated Obstructive Sleep Apnea.
Austin Authors: Jackson, Melinda L ;Rayner, Genevieve ;Wilson, Sarah;Schembri, Rachel M ;Sommers, Lucy;O'Donoghue, Fergal J ;Jackson, Graeme D ;Tailby, Chris 
Affiliation: Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, VIC, Australia
The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia
Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
Institute for Breathing and Sleep
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, VIC, Australia
School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Issue Date: 24-Jun-2020 2020-06-24
Publication information: Frontiers in Neuroscience 2020; 14: 580
Abstract: Obstructive sleep apnea (OSA) is associated with working- and autobiographical-memory impairments, and high rates of mood disorder. This study aimed to examine (i) behavioral responses and (ii) neural activation patterns elicited by autobiographical and working memory tasks in moderate-severe untreated OSA patients and healthy controls, and (iii) whether variability in autobiographical and working memory activation are associated with task performance, OSA severity and psychological symptomatology (depression, anxiety). In order to control for the potential confounding effect of elevated rates of clinical depression in OSA, we excluded individuals with a current psychiatric condition. Seventeen untreated OSA participants and 16 healthy controls were comparable with regards to both activation and behavioral performance. OSA was associated with worse subclinical mood symptoms and poorer personal semantic memory. Higher levels of nocturnal hypoxia were associated with increased activation in the occipital cortex and right cerebellum during the working memory task in OSA participants, however, no significant relationships between activation and task performance or depressive/anxiety symptomatology were observed. The neurocognitive substrates supporting autobiographical recall of recent events and working memory in younger, recently diagnosed individuals with OSA appear to be indistinguishable from healthy age-matched individuals. These findings point to the importance of early diagnosis and treatment of OSA in order to preserve cognitive function.
DOI: 10.3389/fnins.2020.00580
Journal: Frontiers in Neuroscience
PubMed URL: 32670007
ISSN: 1662-4548
Type: Journal Article
Subjects: autobiographical memory network
working memory
Appears in Collections:Journal articles

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