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Title: Arrhythmia insensitive rapid cardiac T1 mapping: comparison to modified look locker inversion recovery T1 mapping in mitral valve prolapse patients.
Austin Authors: Cheung, Ernest ;Han, Hui-Chen ;Hornsey, Emma ;Churilov, Leonid ;Hong, Kyung Pyo;Smith, Julie ;Kim, Daniel;Farouque, Omar ;Teh, Andrew W ;Lim, Han S ;Lim, Ruth P 
Affiliation: Northwestern University, Evanston, USA
The University of Melbourne, Melbourne, Australia
Department of Cardiology, Eastern Health Clinical School, Monash University, Victoria, Australia
BioMedical Engineering and Imaging Institute, Icahn School of Medicine At Mount Sinai, New York, NY, USA
Austin Health, Heidelberg, Victoria, Australia
Issue Date: Oct-2020 2020-06-08
Publication information: The international journal of cardiovascular imaging 2020; 36(10): 2017-2025
Abstract: We compare a saturation recovery arrhythmia insensitive rapid (AIR) T1 mapping technique which is less sensitive to heart rate and requires shorter breath-holds to modified Look-Locker inversion recovery (MOLLI) T1 mapping in patients with mitral valve prolapse. 55 patients underwent AIR and MOLLI at 1.5 T. AIR and MOLLI-derived blood and myocardial T1 values and extracellular volume (ECV) were measured by two independent readers. T1 values and ECV from both techniques and inter-reader agreement were compared with Lin's concordance correlation coefficient (LCC) and reduced major axis regression. T1 values were consistently overestimated for AIR compared to MOLLI and vice versa for ECV. In the mitral valve prolapse population, mean native and post contrast myocardial T1 value for MOLLI were 1000 ± 40 ms and 411.9 ± 44.2 ms respectively and 1090.6 ± 58.7 ms and 488.2 ± 45.7 ms for AIR. Mean native and post contrast blood T1 values for MOLLI were 1566.6 ± 72.3 ms and 276.6 ± 34.1 ms respectively versus 1657.2 ± 180.9 ms and 294.9 ± 35.6 ms for AIR. AIR underestimated ECV relative to MOLLI (23.5 ± 0.4% vs 27.7 ± 0.4%). We found excellent inter-reader agreement (LCC all > 0.94, p < 0.0001) for both AIR and MOLLI techniques as well as intra-reader reliability (LCC all > 0.97, p < 0.0001). AIR can be performed in patients with mitral valve prolapse with excellent inter and intra-reader agreement, with higher T1 values compared to MOLLI, in line with other saturation recovery techniques. A consistent T1 mapping technique should be used when performing serial imaging.
DOI: 10.1007/s10554-020-01910-9
ORCID: 0000-0002-9807-6606
PubMed URL: 32514823
Type: Journal Article
Subjects: Arrhythmia insensitive rapid
Mitral valve prolapse
Modified look-locker inversion recovery
T1 mapping
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