Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/23276
Title: Antiplatelet Drugs for Neurointerventions: Part 1 Clinical Pharmacology.
Authors: Pearce, Samuel;Maingard, Julian T;Li, Kenny;Kok, Hong Kuan;Barras, Christen D;Russell, Jeremy H;Hirsch, Joshua A;Chandra, Ronil V;Jhamb, Ash;Thijs, Vincent N;Brooks, Duncan Mark;Asadi, Hamed
Affiliation: Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Interventional Neuroradiology Service, Department of Radiology, Austin Health, Heidelberg, Victoria, Australia
Interventional Neuroradiology, St Vincent's Hospital, Melbourne, Victoria, Australia
Interventional Neuroradiology Unit, Monash Imaging, Monash Health, Melbourne, Victoria, Australia
School of Medicine, Faculty of Health, Deakin University, Waurn Ponds, Victoria, Australia
Interventional Radiology Service, Department of Radiology, Northern Hospital, Melbourne, Victoria, Australia
South Australian Institute of Health and Medical Research, Adelaide, South Australia, Australia
School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia
Department of Imaging, Monash University, Melbourne, Victoria, Australia
Stroke Division, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia
School of Medicine, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 18-May-2020
EDate: 2020
Citation: Clinical neuroradiology 2020; online first: 18 May
Abstract: The development of endovascular treatment for intracranial aneurysms has established new techniques such as balloon and stent-assistance, flow diversion and endosaccular occlusion devices. Antiplatelet treatment is an important aspect to reduce risk of thrombus formation on microcatheters and implanted devices when utilizing these methods. It is particularly relevant for flow diverting stents to prevent early and late stent thrombosis. Consideration of platelet physiology and appropriate selection of antiplatelet medication is important as platelet dysfunction drives many of the pathological processes and complications of neurointerventional procedures. Part one of this review focuses on basic platelet physiology, pharmacology of common antiplatelet medications and future directions and therapies. Part two focuses on clinical applications and evidence-based therapeutic regimens.
URI: http://ahro.austin.org.au/austinjspui/handle/1/23276
DOI: 10.1007/s00062-020-00910-5
ORCID: 0000-0003-2475-9727
0000-0003-3692-120X
0000-0002-6614-8417
0000-0001-5034-570X
PubMed URL: 32424668
Type: Journal Article
Review
Subjects: Aneurysm
Coiling
Flow diverting
Intracranial
Stent
Appears in Collections:Journal articles

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