Austin Health

Title
Cross-reactivity between vancomycin, teicoplanin and telavancin in HLA-A*32:01 positive vancomycin DRESS patients sharing an HLA-Class II haplotype.
Publication Date
2021-01
Author(s)
Nakkam, Nontaya
Gibson, Andrew
Mouhtouris, Effie
Konvinse, Katherine
Holmes, Natasha E
Chua, Kyra Y L
Deshpande, Pooja
Li, Danmeng
Ostrov, David A
Trubiano, Jason
Phillips, Elizabeth J
Subject
HLA-A*32:01
Vancomycin-induced DRESS
cross-reactivity
teicoplanin
telavancin
Type of document
Journal Article
OrcId
0000-0001-8501-4054
DOI
10.1016/j.jaci.2020.04.056
Abstract
All fifteen patients with HLA-A*32:01 restricted vancomycin-induced DRESS, showed negative ex vivo responses to dalbavancin however two showed cross-reactivity to teicoplanin and telavancin. Adjunctive diagnostic testing should be considered to detect potential cross-reactivity amongst glycopeptides.
Link
Citation
The Journal of Allergy and Clinical Immunology 2021; 147(1): 403-405
Jornal Title
The Journal of Allergy and Clinical Immunology

Files:

NameSizeformatDescriptionLink