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Title: Assessing TEG6S reliability between devices and across multiple time points: A prospective thromboelastography validation study.
Austin Authors: Lloyd-Donald, Patryck ;Churilov, Leonid ;Cheong, Brandon;Bellomo, Rinaldo ;McCall, Peter R ;Mårtensson, Johan;Glassford, Neil J;Weinberg, Laurence 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
Department of Surgery, Austin Health, Heidelberg, Victoria, Australia
Department of Perioperative Medicine and Intensive Care Medicine, Karolinska University Hospital, Solna, and Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77, Stockholm, Sweden
Issue Date: 27-Apr-2020 2020-04-27
Publication information: Scientific Reports 2020-04-27; 10(1): 7045
Abstract: The TEG6S is a novel haemostasis analyser utilising resonance technology. It offers potentially greater coagulation information and ease of use, however has not been independently validated in a clinical setting. We aimed to determine if the TEG6S is reliable between devices and across time points. We performed a prospective observational study with ethical approval. For interdevice reliability, we performed simultaneous analysis on two TEG6S devices on 25 adult ICU patients. For time point reliability, we performed repeated sampling across five different time points on 15 adult participants. Blood was collected with informed consent, or as standard care, before four-channel citrated kaolin analysis. We observed almost perfect interdevice reliability across all TEG parameters. The Lin's concordance correlation coefficients (95% CI, major axis regression slope, intercept) were R-time: 0.96 (0.92-0.99, 0.88, 0.57); K-time: 0.93 (0.87-0.98, 1.07, 0.00); Alpha Angle: 0.87 (0.78-0.96, 1.20, -14.10); Maximum Amplitude: 0.99 (0.98-0.99, 1.02, -1.38); Clot Lysis: 0.89 (0.82-0.97, 1.20, 0.07). Additionally, we observed moderate-to-high reliability across time points. Demonstrating almost perfect agreement across different devices and moderate-to-high reliability across multiple time points, suggests the TEG6S platform can be used with haemostatic accuracy and generalisability. This has potentially significant implications for clinical practice and multi-site research programs.
DOI: 10.1038/s41598-020-63964-y
ORCID: 0000-0001-7403-7680
PubMed URL: 32341418
Type: Journal Article
Appears in Collections:Journal articles

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