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Title: Stability of bicarbonate in normal saline: a technical report.
Austin Authors: Naorungroj, Thummaporn ;Neto, Ary Serpa;Fujii, Tomoko;Jude, Briony;Udy, Andrew;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care and Hyperbaric Medicine, Alfred Hospital, Melbourne, Vic, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Vic, Australia
Issue Date: Mar-2020
Publication information: Critical Care and Resuscitation 2020; 22(1): 83-85
Abstract: The benefit of intravenous sodium bicarbonate administration in patients with severe metabolic acidosis remains controversial, partly due to lack of double-blind trials. From a practical viewpoint, such blinding requires testing of the stability of sodium bicarbonate in polyolefin bags. We examined seven samples of 100 mL 8.4% sodium bicarbonate diluted in 150 mL normal saline within a 250 mL polyolefin bag at time 0, 24 and 48 hours after preparation. We measured pH, Pco2, and bicarbonate concentration. Over a period of 48 hours, both pH and Pco2 decreased significantly (hourly rate of change, -0.001 [P = 0.043) and -0.098 [P < 0.001] respectively). However, the concentration of bicarbonate did not decrease, with an hourly rate of change of only -0.009 (P = 0.42). When 100 mL of 8.4% sodium bicarbonate are diluted in 150 mL of normal saline within a 250 mL polyolefin bag, changes in pH and Pco2 over a 48-hour period are small and bicarbonate concentration remains stable.
ORCID: 0000-0002-1650-8939
PubMed URL: 32102647
ISSN: 1441-2772
Type: Journal Article
Appears in Collections:Journal articles

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