Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22693
Title: Outcome measurement in functional neurological disorder: a systematic review and recommendations.
Austin Authors: Pick, Susannah;Anderson, David G;Asadi-Pooya, Ali A;Aybek, Selma;Baslet, Gaston;Bloem, Bastiaan R;Bradley-Westguard, Abigail;Brown, Richard J;Carson, Alan J;Chalder, Trudie;Damianova, Maria;David, Anthony S;Edwards, Mark J;Epstein, Steven A;Espay, Alberto J;Garcin, Béatrice;Goldstein, Laura H;Hallett, Mark;Jankovic, Joseph;Joyce, Eileen M;Kanaan, Richard A A ;Keynejad, Roxanne C;Kozlowska, Kasia;LaFaver, Kathrin;LaFrance, W Curt;Lang, Anthony E;Lehn, Alex;Lidstone, Sarah;Maurer, Carine W;Mildon, Bridget;Morgante, Francesca;Myers, Lorna;Nicholson, Clare;Nielsen, Glenn;Perez, David L;Popkirov, Stoyan;Reuber, Markus;Rommelfanger, Karen S;Schwingenshuh, Petra;Serranova, Tereza;Shotbolt, Paul;Stebbins, Glenn T;Stone, Jon;Tijssen, Marina Aj;Tinazzi, Michele;Nicholson, Timothy R
Affiliation: Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA
Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa
Epilepsy Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran, Islamic Republic of
Mater Neurosciences Centre, Brisbane, Queensland, Australia
Discipline of Psychiatry and Child and Adolescent Health, The Children's Hospital at Westmead, Sydney Medical School, Sydney, New South Wales, Australia
Department of Psychiatry, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Neurology, Hopital Avicenne, Assistance Publique, Hôpitaux de Paris, Paris, Île-de-France, France
Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Department of Psychiatry, Georgetown University, Washington, District of Columbia, USA
Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Department of Neurology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA
FND Hope International, Salmon, Idaho, USA
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
Departments of Psychiatry and Neurology, Rhode Island Hospital, Brown Medical School, Providence, RI, USA
Northeast Regional Epilepsy Group, New York, New York, USA
Departments of Neurology and Psychiatry and Behavioral Sciences, Emory Centre for Ethics, Emory University School of Medicine, Atlanta, Georgia, USA
Department of Neurology, University Hospital Bern & University of Bern, Bern, Switzerland
Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands
School of Health Sciences, The University of Manchester, Manchester, UK
Department of Clinical Neurosciences, School of Molecular and Clinical Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa
Institute of Mental Health, Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom
Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
University College London Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, University Health Network, Toronto, Ontario, Canada
Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK
Therapy Services, The National Hospital for Neurology and Neurosurgery, London, UK
Neuroscience Research Centre, Institute of Molecular and Clinical Sciences, St George's University, London, UK
Departments of Neurology and Psychiatry, Therapy Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States
Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany
Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
Department of Neurology, Medical University of Graz, Graz, Austria
Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Prague, Czech Republic
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Department of Clinical Neurosciences, School of Molecular and Clinical Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK
Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Department of Neuroscience, Biomedicine, and Movement, University of Verona, Verona, Italy
Issue Date: Jun-2020
metadata.dc.date: 2020-02-28
Publication information: Journal of neurology, neurosurgery, and psychiatry 2020; 91(6): 638-649
Abstract: We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes. A systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discussed during two international meetings of the FND-Core Outcome Measures group. Five FND-specific measures were identified-three clinician-rated and two patient-rated-but their measurement properties have not been rigorously evaluated. No single measure was identified for use across the range of FND symptoms in adults. Across randomised controlled trials (k=40) and observational treatment studies (k=40), outcome measures most often assessed core FND symptom change. Other domains measured commonly were additional physical and psychological symptoms, life impact (ie, quality of life, disability and general functioning) and health economics/cost-utility (eg, healthcare resource use and quality-adjusted life years). There are few well-validated FND-specific outcome measures. Thus, at present, we recommend that existing outcome measures, known to be reliable, valid and responsive in FND or closely related populations, are used to capture key outcome domains. Increased consistency in outcome measurement will facilitate comparison of treatment effects across FND symptom types and treatment modalities. Future work needs to more rigorously validate outcome measures used in this population.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22693
DOI: 10.1136/jnnp-2019-322180
ORCID: 0000-0003-2001-6723
0000-0002-2598-7601
0000-0002-7877-6760
0000-0002-6371-3337
0000-0003-3961-2023
0000-0002-7425-0964
0000-0003-0775-1045
0000-0003-0967-774X
0000-0002-8283-9015
0000-0002-3389-136X
0000-0001-9109-9904
0000-0001-9387-3035
0000-0002-3180-6811
0000-0003-4129-3674
0000-0003-0469-2844
0000-0003-0992-1917
0000-0003-4434-3526
0000-0002-9578-0753
0000-0001-5416-894X
0000-0002-4901-3852
0000-0003-1229-3667
0000-0003-2780-6496
0000-0002-0147-0202
0000-0002-7892-7127
0000-0001-7191-3163
0000-0002-9834-3639
0000-0001-7706-9952
0000-0002-8047-6820
0000-0001-6053-5670
0000-0003-2721-583X
0000-0001-6168-0036
0000-0002-4104-6705
0000-0002-2667-1190
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0000-0001-7905-9336
0000-0001-9829-8092
0000-0001-5783-571X
0000-0002-2370-7063
0000-0002-2350-2332
PubMed URL: 32111637
Type: Journal Article
Subjects: clinical neurology
conversion disorder
functional neurological disorder
movement disorders
neuropsychiatry
Appears in Collections:Journal articles

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