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Title: Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer's Disease.
Austin Authors: Yassi, Nawaf;Hilal, Saima;Xia, Ying;Lim, Yen Ying;Watson, Rosie;Kuijf, Hugo;Fowler, Christopher;Yates, Paul A ;Maruff, Paul;Martins, Ralph;Ames, David;Chen, Christopher;Rowe, Christopher;Villemagne, Victor;Salvado, Olivier;Desmond, Patricia M;Masters, Colin L 
Affiliation: Geriatric Medicine
The Australian e-Health Research Centre, BioMedIA, Royal Brisbane and Women's Hospital, Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia
Molecular Imaging and Therapy
Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Perth, Australia
Cogstate Ltd, Melbourne, VIC, Australia
National University Hospital of Singapore, National University of Singapore, Singapore
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia
Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Academic Unit for Psychiatry of Old Age, University of Melbourne, Parkville, Australia
National Ageing Research Institute, Parkville, Australia
Department of Florey, University of Melbourne, Parkville, Australia
Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
Image Sciences Institute, University Medical Center, Utrecht, Utrecht, Netherlands
National University Hospital of Singapore, National University of Singapore, Singapore
Issue Date: 2020
Date: 2019-12-23
Publication information: Journal of Alzheimer's disease : JAD 2020; 73(3): 987-907
Abstract: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer's disease is challenging. We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. Two-hundred and eighteen participants underwent Aβ PET, MRI, and cognitive assessment at 18-month intervals for up to 90 months. Aβ status was determined on baseline PET. Participants were also classified as V + on baseline MRI if they had≥1 large cortical infarcts, subcortical infarcts, or cortical cerebral microinfarcts; or white matter hyperintensity volume greater than the 90th percentile of healthy controls. Linear mixed models were conducted comparing slopes of change in cognition, hippocampal volume, and Aβ load between the four resultant groups. Mean age at baseline was 74 years (range 59-96). One-hundred and fifteen participants were cognitively normal, 54 had mild cognitive impairment, and 49 had Alzheimer's disease. Compared to the Aβ-/V- group, the Aβ+/V- and Aβ+/V+groups showed significantly faster cognitive decline and hippocampal atrophy over 90 months. V + status was associated with greater cognitive decline (Cohen's d = 0.85, p < 0.001) and hippocampal atrophy (d = 2.05, p < 0.001) in the Aβ+group but not in the Aβ- group. V + status was not associated with Aβ accumulation in any group. Comorbidity of cerebrovascular disease and Aβ was associated with cognitive decline and neurodegeneration. Cerebrovascular disease was not associated with the rate of Aβ accumulation.
DOI: 10.3233/JAD-191028
ORCID: 0000-0003-3910-2453
Journal: Journal of Alzheimer's disease : JAD
PubMed URL: 31884485
Type: Journal Article
Subjects: Alzheimer’s disease
cerebrovascular disease
magnetic resonance imaging
mild cognitive impairment
positron emission tomography
Appears in Collections:Journal articles

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