Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22283
Title: Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference.
Austin Authors: Norris, Rebecca H C;Churilov, Leonid ;Hannan, Anthony J;Nithianantharajah, Jess
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Florey Department of Neuroscience, University of Melbourne, Parkville, Victoria Australia
Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, Victoria Australia
Issue Date: 2-Dec-2019
metadata.dc.date: 2019-12-02
Publication information: Molecular autism 2019; 10: 42
Abstract: Cognitive dysfunction including disrupted behavioral flexibility is central to neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). A cognitive measure that assesses relational memory, and the ability to flexibly assimilate and transfer learned information is transitive inference. Transitive inference is highly conserved across vertebrates and disrupted in cognitive disorders. Here, we examined how mutations in the synaptic cell-adhesion molecule neuroligin-3 (Nlgn3) that have been documented in ASD impact relational memory and behavioral flexibility. We first refined a rodent touchscreen assay to measure visual transitive inference, then assessed two mouse models of Nlgn3 dysfunction (Nlgn3-/y and Nlgn3R451C). Deep analysis of touchscreen behavioral data at a trial level established we could measure trajectories in flexible responding and changes in processing speed as cognitive load increased. We show that gene mutations in Nlgn3 do not disrupt relational memory, but significantly impact flexible responding. Our study presents the first analysis of reaction times in a rodent transitive inference test, highlighting response latencies from the touchscreen system are useful indicators of processing demands or decision-making processes. These findings expand our understanding of how dysfunction of key components of synaptic signaling complexes impact distinct cognitive processes disrupted in neurodevelopmental disorders, and advance our approaches for dissecting rodent behavioral assays to provide greater insights into clinically relevant cognitive symptoms.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22283
DOI: 10.1186/s13229-019-0292-2
ORCID: 0000-0002-3501-1143
0000-0002-9807-6606
PubMed URL: 31827744
Type: Journal Article
Subjects: Autism spectrum disorder
Perseveration
Processing speed
Reaction time
Synapse
Appears in Collections:Journal articles

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