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Title: | Increasing Prevalence of Primary Biliary Cholangitis in Victoria, Australia. | Austin Authors: | French, Janine ;van der Mei, Ingrid;Simpson, Steve;Ng, Justin;Angus, Peter W ;Lubel, John;Nicoll, Amanda;Sood, Siddharth ;Roberts, Stuart K;Kemp, William;Arachchi, Niranjan;Dev, Anouk;Thompson, Alexander;Gow, Paul J | Affiliation: | Gastroenterology and Hepatology Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia Melbourne School of Population & Global Health, The University of Melbourne, Carlton, Australia Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia The University of Melbourne, Victoria, Australia Department of Gastroenterology, Eastern Health, Box Hill, Australia Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, Parkville, Australia Department of Gastroenterology and Hepatology, The Alfred, Melbourne, Australia Department of Gastroenterology and Hepatology, Western Hospital, Footscray, Australia Department of Gastroenterology and Hepatology, Monash Health, Clayton, Australia Monash University, Victoria, Australia Department of Gastroenterology, St Vincent's Hospital, Fitzroy, Australia The University of Melbourne, Victoria, Australia |
Issue Date: | Apr-2020 | Date: | 2019-11-06 | Publication information: | Journal of Gastroenterology and Hepatology 2020; 35(4): 673-679 | Abstract: | The prevalence of primary biliary cholangitis (PBC) reported in different countries varies significantly and in some parts of the world appears to be increasing. The aim of this study was to determine the 2013 prevalence of PBC in Victoria, Australia, and to determine the time trend by comparing it to previous studies undertaken in 1991 and 2002. Four case-finding methods were used to identify cases of PBC in Victoria. 1. Physicians' survey; 2. Tertiary hospital search; 3. Liver Transplant Database search; 4. Private Pathology Anti-Mitochondrial Antibody (AMA) search. The prevalence of PBC in Victoria Australia is 189.0 per million using all four methods. The average annual increase in prevalence from 1991 to 2013 was 7.7 per million per year. Using the same case finding methods as the 1991 Victorian prevalence study (methods 1, 2), the prevalence of PBC increased from 19.1 per million in 1991 to 49.4 per million in 2002 (p<0.001) and to 80.7 per million in 2013 (p<0.001.) CONCLUSIONS: The current prevalence of PBC in Victoria is significantly higher than previously reported. The use of private pathology-based case-finding methods is important in identifying the maximum number of PBC cases. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/22071 | DOI: | 10.1111/jgh.14924 | ORCID: | 0000-0003-0630-5916 0000-0002-1855-2757 |
Journal: | Journal of Gastroenterology and Hepatology | PubMed URL: | 31693755 | Type: | Journal Article | Subjects: | autoimmune liver disease epidemiology primary biliary cirrhosis |
Appears in Collections: | Journal articles |
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