Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/22071
Title: Increasing Prevalence of Primary Biliary Cholangitis in Victoria, Australia.
Austin Authors: French, Janine ;van der Mei, Ingrid;Simpson, Steve;Ng, Justin;Angus, Peter W ;Lubel, John;Nicoll, Amanda;Sood, Siddharth ;Roberts, Stuart K;Kemp, William;Arachchi, Niranjan;Dev, Anouk;Thompson, Alexander;Gow, Paul J 
Affiliation: Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Melbourne School of Population & Global Health, The University of Melbourne, Carlton, Australia
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia
The University of Melbourne, Victoria, Australia
Department of Gastroenterology, Eastern Health, Box Hill, Australia
Department of Gastroenterology and Hepatology, Royal Melbourne Hospital, Parkville, Australia
Department of Gastroenterology and Hepatology, The Alfred, Melbourne, Australia
Department of Gastroenterology and Hepatology, Western Hospital, Footscray, Australia
Department of Gastroenterology and Hepatology, Monash Health, Clayton, Australia
Monash University, Victoria, Australia
Department of Gastroenterology, St Vincent's Hospital, Fitzroy, Australia
The University of Melbourne, Victoria, Australia
Issue Date: Apr-2020
metadata.dc.date: 2019-11-06
Publication information: Journal of Gastroenterology and Hepatology 2020; 35(4): 673-679
Abstract: The prevalence of primary biliary cholangitis (PBC) reported in different countries varies significantly and in some parts of the world appears to be increasing. The aim of this study was to determine the 2013 prevalence of PBC in Victoria, Australia, and to determine the time trend by comparing it to previous studies undertaken in 1991 and 2002. Four case-finding methods were used to identify cases of PBC in Victoria. 1. Physicians' survey; 2. Tertiary hospital search; 3. Liver Transplant Database search; 4. Private Pathology Anti-Mitochondrial Antibody (AMA) search. The prevalence of PBC in Victoria Australia is 189.0 per million using all four methods. The average annual increase in prevalence from 1991 to 2013 was 7.7 per million per year. Using the same case finding methods as the 1991 Victorian prevalence study (methods 1, 2), the prevalence of PBC increased from 19.1 per million in 1991 to 49.4 per million in 2002 (p<0.001) and to 80.7 per million in 2013 (p<0.001.) CONCLUSIONS: The current prevalence of PBC in Victoria is significantly higher than previously reported. The use of private pathology-based case-finding methods is important in identifying the maximum number of PBC cases.
URI: http://ahro.austin.org.au/austinjspui/handle/1/22071
DOI: 10.1111/jgh.14924
ORCID: 0000-0003-0630-5916
0000-0002-1855-2757
PubMed URL: 31693755
Type: Journal Article
Subjects: autoimmune liver disease
epidemiology
primary biliary cirrhosis
Appears in Collections:Journal articles

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