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Title: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.
Austin Authors: Ljimani, Alexandra;Caroli, Anna;Laustsen, Christoffer;Francis, Susan;Mendichovszky, Iosif Alexandru;Bane, Octavia;Nery, Fabio;Sharma, Kanishka;Pohlmann, Andreas;Dekkers, Ilona A;Vallee, Jean-Paul;Derlin, Katja;Notohamiprodjo, Mike;Lim, Ruth P ;Palmucci, Stefano;Serai, Suraj D;Periquito, Joao;Wang, Zhen Jane;Froeling, Martijn;Thoeny, Harriet C;Prasad, Pottumarthi;Schneider, Moritz;Niendorf, Thoralf;Pullens, Pim;Sourbron, Steven;Sigmund, Eric E
Affiliation: MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Sir Peter Mansfield Imaging Centre, University Park, University of Nottingham, Nottingham, NG7 2RD, UK
Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK
Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, UK
Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK
Department of Diagnostic, Geneva University Hospital and University of Geneva, 1211, Geneva-14, Switzerland
Department of Radiology, Hôpital Cantonal Fribourgois (HFR), University of Fribourg, 1708, Fribourg, Switzerland
Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK
Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125, Berlin, Germany
Department of Medical Surgical Sciences and Advanced Technologies, Radiology I Unit, University Hospital "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy
Department of Radiology, Hannover Medical School, Hannover, Germany
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Radiology, Center for Biomedical Imaging (CBI), Center for Advanced Imaging Innovation and Research (CAI2R), NYU Langone Health, New York, NY, USA
Department of Radiology, Center for Advanced Imaging, NorthShore University Health System, Evanston, IL, USA
Comprehensive Pneumology Center, German Center for Lung Research, Munich, Germany
Department of Radiology, University Hospital Tuebingen, Tübingen, Germany
Department of Biomedical Engineering, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy
Department of Radiology, Austin Health, Heidelberg, Victoria, Australia
Die Radiologie, Munich, Germany
Ghent Institute for Functional and Metabolic Imaging, Ghent University, Ghent, Belgium
Department of Radiology, University Hospital Ghent, Ghent, Belgium
Department of Radiology, University Hospital, LMU Munich, Munich, Germany
The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 1-Nov-2019 2019-11-01
Publication information: Magma (New York, N.Y.) 2019; online first: 1 November
Abstract: Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.
DOI: 10.1007/s10334-019-00790-y
ORCID: 0000-0002-9748-9927
PubMed URL: 31676990
Type: Journal Article
Subjects: ADC
Appears in Collections:Journal articles

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