Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

2019-11-01

Ljimani, Alexandra

Caroli, Anna

Laustsen, Christoffer

Francis, Susan

Mendichovszky, Iosif Alexandru

Bane, Octavia

Nery, Fabio

Sharma, Kanishka

Pohlmann, Andreas

Dekkers, Ilona A

Vallee, Jean-Paul

Derlin, Katja

Notohamiprodjo, Mike

Lim, Ruth P

Palmucci, Stefano

Serai, Suraj D

Periquito, Joao

Wang, Zhen Jane

Froeling, Martijn

Thoeny, Harriet C

Prasad, Pottumarthi

Schneider, Moritz

Niendorf, Thoralf

Pullens, Pim

Sourbron, Steven

Sigmund, Eric E

ADC

Biomarker

DTI

DWI

IVIM

Journal Article

0000-0002-9748-9927

0000-0002-4130-4663

0000-0003-3841-0497

10.1007/s10334-019-00790-y

Standardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization. Reported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement. Correlations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided. The consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

link

Magma (New York, N.Y.) 2019; online first: 1 November

Magma (New York, N.Y.)