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Title: Osteocalcin and its forms across the lifespan in adult men.
Austin Authors: Smith, Cassandra;Voisin, Sarah;Al Saedi, Ahmed;Phu, Steven;Brennan-Speranza, Tara;Parker, Lewan;Eynon, Nir;Hiam, Danielle;Yan, Xu;Scott, David;Blekkenhorst, Lauren C;Lewis, Joshua R;Seeman, Ego ;Byrnes, Elizabeth;Flicker, Leon;Duque, Gustavo;Yeap, Bu B;Levinger, Itamar 
Affiliation: Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australia
School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia
Department of Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australia
Medical School, University of Western Australia, Perth, Australia
Western Australian Centre for Health & Ageing, University of Western Australia, Perth, Australia
University of Melbourne, Melbourne, Australia
Institute for Health and Sport (iHeS), Victoria University, Melbourne, VIC, Australia
Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia
Department of Physiology and Bosch Institute for Medical Research, University of Sydney, New South Wales, Australia
Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia
Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia
Murdoch Childrens Research Institute, Melbourne, Australia
School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia
Mary Mackillop Institute of Healthy Aging, Australian Catholic University, Melbourne, Australia
Issue Date: Jan-2020
Date: 2019-10-14
Publication information: Bone 2020; 130: 115085
Abstract: Osteocalcin (OC), an osteoblast-specific secreted protein expressed by mature osteoblasts, is used in clinical practice and in research as a marker of bone turnover. The carboxylated (cOC) and undercarboxylated (ucOC) forms may have a different biological function but age-specific reference ranges for these components are not established. Given the different physiological roles, development of reference ranges may help to identify people at risk for bone disease. Blood was collected in the morning after an overnight fast from 236 adult men (18 to 92 years old) free of diabetes, antiresorptive, warfarin or glucocorticoid use. Serum was analyzed for total osteocalcin (tOC) and the ucOC fraction using the hydroxyapatite binding method. cOC, ucOC/tOC and cOC/tOC ratios were calculated. Reference intervals were established by polynomial quantile regression analysis. The normal ranges for young men (≤ 30 years) were: tOC 17.9-56.8 ng/mL, ucOC 7.1-22.0 ng/mL, cOC 8.51-40.3 ng/mL (2.5th to 97.5th quantiles). Aging was associated with a "U" shaped pattern for tOC, cOC and ucOC levels. ucOC/tOC ratio was higher, while cOC/tOC ratio was lower in men of advanced age. Age explained ∼31%, while body mass index explained ∼4%, of the variance in the ratios. We have defined normal reference ranges for the OC forms in Australian men and demonstrated that the OC ratios may be better measures, than the absolute values, to identify the age-related changes on OC in men. These ratios may be incorporated into future research and clinical trials, and their associations with prediction of events, such as fracture or diabetes risk, should be determined.
DOI: 10.1016/j.bone.2019.115085
Journal: Bone
PubMed URL: 31622778
Type: Journal Article
Subjects: Osteocalcin
bone turnover
reference ranges
Appears in Collections:Journal articles

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