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dc.contributor.authorSmith, Cassandra-
dc.contributor.authorVoisin, Sarah-
dc.contributor.authorAl Saedi, Ahmed-
dc.contributor.authorPhu, Steven-
dc.contributor.authorBrennan-Speranza, Tara-
dc.contributor.authorParker, Lewan-
dc.contributor.authorEynon, Nir-
dc.contributor.authorHiam, Danielle-
dc.contributor.authorYan, Xu-
dc.contributor.authorScott, David-
dc.contributor.authorBlekkenhorst, Lauren C-
dc.contributor.authorLewis, Joshua R-
dc.contributor.authorSeeman, Ego-
dc.contributor.authorByrnes, Elizabeth-
dc.contributor.authorFlicker, Leon-
dc.contributor.authorDuque, Gustavo-
dc.contributor.authorYeap, Bu B-
dc.contributor.authorLevinger, Itamar-
dc.identifier.citationBone 2020; 130: 115085en_US
dc.description.abstractOsteocalcin (OC), an osteoblast-specific secreted protein expressed by mature osteoblasts, is used in clinical practice and in research as a marker of bone turnover. The carboxylated (cOC) and undercarboxylated (ucOC) forms may have a different biological function but age-specific reference ranges for these components are not established. Given the different physiological roles, development of reference ranges may help to identify people at risk for bone disease. Blood was collected in the morning after an overnight fast from 236 adult men (18 to 92 years old) free of diabetes, antiresorptive, warfarin or glucocorticoid use. Serum was analyzed for total osteocalcin (tOC) and the ucOC fraction using the hydroxyapatite binding method. cOC, ucOC/tOC and cOC/tOC ratios were calculated. Reference intervals were established by polynomial quantile regression analysis. The normal ranges for young men (≤ 30 years) were: tOC 17.9-56.8 ng/mL, ucOC 7.1-22.0 ng/mL, cOC 8.51-40.3 ng/mL (2.5th to 97.5th quantiles). Aging was associated with a "U" shaped pattern for tOC, cOC and ucOC levels. ucOC/tOC ratio was higher, while cOC/tOC ratio was lower in men of advanced age. Age explained ∼31%, while body mass index explained ∼4%, of the variance in the ratios. We have defined normal reference ranges for the OC forms in Australian men and demonstrated that the OC ratios may be better measures, than the absolute values, to identify the age-related changes on OC in men. These ratios may be incorporated into future research and clinical trials, and their associations with prediction of events, such as fracture or diabetes risk, should be determined.en_US
dc.subjectbone turnoveren_US
dc.subjectreference rangesen_US
dc.titleOsteocalcin and its forms across the lifespan in adult men.en_US
dc.typeJournal Articleen_US
dc.identifier.affiliationDepartment of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australiaen_US
dc.identifier.affiliationSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australiaen_US
dc.identifier.affiliationCentre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australiaen_US
dc.identifier.affiliationDepartment of Biochemistry, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Perth, Australiaen_US
dc.identifier.affiliationMedical School, University of Western Australia, Perth, Australiaen_US
dc.identifier.affiliationWestern Australian Centre for Health & Ageing, University of Western Australia, Perth, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Australiaen_US
dc.identifier.affiliationInstitute for Health and Sport (iHeS), Victoria University, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationInstitute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australiaen_US
dc.identifier.affiliationDepartment of Physiology and Bosch Institute for Medical Research, University of Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationAustralian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australiaen_US
dc.identifier.affiliationDepartment of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationMurdoch Childrens Research Institute, Melbourne, Australiaen_US
dc.identifier.affiliationSchool of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australiaen_US
dc.identifier.affiliationMary Mackillop Institute of Healthy Aging, Australian Catholic University, Melbourne, Australiaen_US
dc.type.austinJournal Article-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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