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Title: The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol.
Austin Authors: Gaudino, Mario;Benedetto, Umberto;Fremes, Stephen;Ballman, Karla;Biondi-Zoccai, Giuseppe;Sedrakyan, Art;Nasso, Giuseppe;Raman, Jai S ;Buxton, Brian;Hayward, Philip A;Moat, Neil;Collins, Peter;Webb, Carolyn;Peric, Miodrag;Petrovic, Ivana;Yoo, Kyung J;Hameed, Irbaz;Di Franco, Antonino;Moscarelli, Marco;Speziale, Giuseppe;Girardi, Leonard N;Hare, David L ;Taggart, David P
Affiliation: Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA
Department of Cardiac Surgery, Bristol Heart Institute, Bristol, UK
Department of Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY, USA
Anthea Hospital, Bari, Italy
NHLI, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, UK
Dedinje Cardiovascular Institute and Belgrade University School of Medicine, Belgrade, Serbia
Yonsei University College of Medicine, Seoul, South Korea
Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA
Anthea Hospital, Bari, Italy
Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Mediterranea Cardiocentro, Naples, Italy
Austin Health
Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University, Rome, Italy
Issue Date: 18-Sep-2019
Date: 2019-09-18
Publication information: European Journal of Cardio-thoracic Surgery 2019; 56(6): 1025-1030
Abstract: It is generally accepted that radial artery (RA) grafts have better mid-term patency rate compared to saphenous vein grafts. However, the clinical correlates of the improved patency rate are still debated. Observational studies have suggested increased survival and event-free survival for patients who receive an RA rather than a saphenous vein, but they are open to bias and confounders. The only evidence based on randomized data is a pooled meta-analysis of 6 randomized controlled trial comparing the RA and the saphenous vein published by the RADial artery International Alliance (RADIAL). In the RADIAL database, improved freedom from follow-up cardiac events (death, myocardial infarction and repeat revascularization) was found at 5-year follow-up in the RA arm. The most important limitation of the RADIAL analysis is that most of the included trials had an angiographic follow-up in the first 5 years and it is unclear whether the rate of repeat revascularization (the main driver of the composite outcome) was clinically indicated due to per-protocol angiographies. Here, we present the protocol for the long-term analysis of the RADIAL database. By extending the follow-up beyond the 5th postoperative year (all trials except 1 did not have angiographic follow-up beyond 5 years), we aim to provide data on the role of RA in coronary artery bypass surgery with respect to long-term outcomes.
DOI: 10.1093/ejcts/ezz247
Journal: European Journal of Cardio-thoracic Surgery
PubMed URL: 31535147
Type: Journal Article
Subjects: Arteries
Coronary artery bypass
Myocardial revascularization
Radial Artery Patency Study
Radial Artery Versus Saphenous Vein Patency trial
Appears in Collections:Journal articles

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