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Title: Diagnostic performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation at estimating glomerular filtration rate in adults with diabetes mellitus: a systematic review and meta-analysis protocol.
Austin Authors: Zafari, Neda;Churilov, Leonid ;MacIsaac, Richard J;Torkamani, Niloufar ;Baxter, Helen ;Kiburg, Katerina V;Ekinci, Elif I 
Affiliation: Medicine (University of Melbourne)
The Florey Institute of Neuroscience and Mental Health
Department of Endocrinology & Diabetes, St Vincent's Hospital, The University of Melbourne, Fitzroy, Melbourne, Victoria, Australia
Austin Health Sciences Library
Issue Date: 30-Aug-2019
Date: 2019-08-30
Publication information: BMJ Open 2019; 9(8): e031558
Abstract: Timely detection leading to the implementation of reno-protective measures reduces the progression of diabetic kidney disease. Estimated glomerular filtration rate (eGFR) is a major surrogate of kidney function. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation is a tool to estimate GFR. This protocol outlines a systematic-review, assessing the diagnostic accuracy of the CKD-EPI equation in adults with diabetes. MEDLINE, Embase, Cochrane Central Register of Controlled Trials and grey literature will be searched for publications in English, Farsi, Dutch and Chinese from 2009 (when CKD-EPI was first introduced) to January 2019. Bridging searches will be conducted to capture literature published from January 2019 until final review publication. The inclusion criteria will be (1) study participants with diabetes; (2) age ≥18 years; (3) creatinine-based CKD-EPI eGFR as index test; (4) measured GFR using the clearance/plasma disappearance of inulin, iohexol, iothalamate, diethylenetriamine-pentaacetic acid (DTPA) or chromium labelled ethylenediaminetetraacetic acid (Cr-EDTA) as reference test; (5) report of the diagnostic accuracy of the index test. Exclusion criteria will be participants with renal transplant, chronic use of corticosteroids, chronic inflammatory diseases, pregnancy, non-diabetes related kidney disease, thalassaemia, heart failure, pregnancy and potential kidney donors as well as critically ill patients. Screening, eligibility check, risk of bias assessment and data extraction will be carried out by two independent reviewers. Any discrepancies will be discussed, and third-party opinion will be sought. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A quantitative synthesis of the aggregated-data will be used if the included studies are homogenous. No ethics approval is required. The outcome will be published in a peer-reviewed journal. The results will help researchers and clinicians evaluate the diagnostic accuracy of the creatinine-based CKD-EPI eGFR in adults with diabetes. CRD42018108776.
DOI: 10.1136/bmjopen-2019-031558
ORCID: 0000-0002-9807-6606
Journal: BMJ Open
PubMed URL: 31473625
Type: Journal Article
Subjects: CKD-EPI
Diabetes mellitus
diabetic kidney disease
glomerular filtration rate
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