Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/21520
Title: High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing.
Austin Authors: Meher-Homji, Zaal;Tam, Constantine S;Siderov, Jim ;Seymour, John Francis;Holmes, Natasha E ;Chua, Kyra Y L ;Phillips, Elizabeth J;Slavin, Monica A;Trubiano, Jason A 
Affiliation: Department of Medicine, University of Melbourne, Melbourne, Australia
Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia
Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Department of Haematology, St Vincents Hospital, Melbourne, Australia
Department of Haematology, Royal Melbourne Hospital, Melbourne, Australia
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Issue Date: 1-Jul-2019
metadata.dc.date: 2019-07-01
Publication information: Leukemia & Lymphoma 2019; 60(14): 3455-3460
Abstract: The relationship between hematological malignancy and chemotherapy on the prevalence of antibiotic allergy label (AAL) is ill-defined. We performed a multicenter retrospective case-control study comparing AAL rates among cladribine-treated hairy cell leukemia (C-HCL) cases, non-HCL cladribine-treated controls (control-1), and fludarabine-treated controls (control-2). The prevalence of AALs in C-HCL patients was 60%, compared with control-1 (14%, p < .01) and control-2 patients (25%, p < .01). The predominant phenotype was maculopapular exanthem (92%). The drugs implicated in AAL causality in C-HCL patients included beta-lactams (81%), trimethoprim-sulfamethoxazole (58%), and allopurinol (69%). C-HCL patients demonstrate high rates of AAL, potentially due to immune dysregulation, impacting beta-lactam utilization.
URI: http://ahro.austin.org.au/austinjspui/handle/1/21520
DOI: 10.1080/10428194.2019.1633640
ORCID: 0000-0003-4636-3678
0000-0002-9759-5017
0000-0003-2188-6835
0000-0001-8501-4054
0000-0002-8443-314X
0000-0002-5111-6367
PubMed URL: 31256738
Type: Journal Article
Subjects: Hairy cell leukemia
allergy
antibiotics
cladribine
maculopapular exanthem
Appears in Collections:Journal articles

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