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Title: | High prevalence of antibiotic allergies in cladribine-treated patients with hairy cell leukemia - lessons for immunopathogenesis and prescribing. | Austin Authors: | Meher-Homji, Zaal;Tam, Constantine S;Siderov, Jim ;Seymour, John Francis;Holmes, Natasha E ;Chua, Kyra Y L ;Phillips, Elizabeth J;Slavin, Monica A;Trubiano, Jason | Affiliation: | Department of Medicine, University of Melbourne, Melbourne, Australia Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Australia Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Australia Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Haematology, St Vincents Hospital, Melbourne, Australia Department of Haematology, Royal Melbourne Hospital, Melbourne, Australia Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA |
Issue Date: | 1-Jul-2019 | Date: | 2019-07-01 | Publication information: | Leukemia & Lymphoma 2019; 60(14): 3455-3460 | Abstract: | The relationship between hematological malignancy and chemotherapy on the prevalence of antibiotic allergy label (AAL) is ill-defined. We performed a multicenter retrospective case-control study comparing AAL rates among cladribine-treated hairy cell leukemia (C-HCL) cases, non-HCL cladribine-treated controls (control-1), and fludarabine-treated controls (control-2). The prevalence of AALs in C-HCL patients was 60%, compared with control-1 (14%, p < .01) and control-2 patients (25%, p < .01). The predominant phenotype was maculopapular exanthem (92%). The drugs implicated in AAL causality in C-HCL patients included beta-lactams (81%), trimethoprim-sulfamethoxazole (58%), and allopurinol (69%). C-HCL patients demonstrate high rates of AAL, potentially due to immune dysregulation, impacting beta-lactam utilization. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/21520 | DOI: | 10.1080/10428194.2019.1633640 | ORCID: | 0000-0003-4636-3678 0000-0002-9759-5017 0000-0003-2188-6835 0000-0001-8501-4054 0000-0002-8443-314X 0000-0002-5111-6367 |
Journal: | Leukemia & Lymphoma | PubMed URL: | 31256738 | Type: | Journal Article | Subjects: | Hairy cell leukemia allergy antibiotics cladribine maculopapular exanthem |
Appears in Collections: | Journal articles |
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