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Title: Young adults diagnosed with high grade gliomas: Patterns of care, outcomes, and impact on employment.
Austin Authors: Hafeez, Umbreen ;Menon, Siddarth;Nguyen, Bella;Lum, Caroline;Gaughran, Gregory;Pranavan, Ganesalingham;Cher, Lawrence;Nowak, Anna K;Gan, Hui K ;Parakh, Sagun 
Affiliation: Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Medical School, University of Western, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Canberra Hospital, Canberra, Australia
Department of Medicine, University of Melbourne, Melbourne, Australia
La Trobe University School of Cancer Medicine, Melbourne, Australia
Sir Charles Gairdner Hospital, Perth, Australia
Monash Health, Melbourne, Australia
Issue Date: Oct-2019 2019-07-29
Publication information: Journal of Clinical Neuroscience 2019; 68: 45-50
Abstract: There is limited information on the patterns of care and outcomes of high grade gliomas (HGGs) in young adults, in particular, the impact it has on a person's employment. We retrospectively identified young adult patients (age ≤ 40 years old) with newly diagnosed high grade gliomas treated between January 2013 and June 2018 across four major neuro-oncology centres in Australia. Patient demographics, tumour characteristics and treatment parameters were collected and outcomes determined. A total of 113 patients were identified with a median follow up of 27.0 months (range 1.0-70.2 months). The median age was 31 years, majority were male (65%) and employed (71.6%). IDH mutations were detected in 66 (62%) cases. The median progression-free survival (PFS) was 38.0 months (95% CI 23.3-52.7 months) and median overall survival (OS) was not reached. Patients with IDH wild type anaplastic astrocytoma and glioblastoma had a significantly shorter median PFS (19.3 months vs. NR, p = 0.001) and median OS (43.5 months vs NR, p = 0.007) than those with IDH mutated grade III anaplastic astrocytoma and oligodendroglioma. There was no significant difference in median OS or PFS between patients who underwent gross or subtotal tumour resection. Significantly, after diagnosis only 36 (32%) patients reported being employed. Young patients with IDH wild type astrocytomas and glioblastoma had better outcomes than reported historical controls. Most patients did not continue in employment post diagnosis.
DOI: 10.1016/j.jocn.2019.07.063
ORCID: 0000-0003-3891-2489
Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
PubMed URL: 31371189
Type: Journal Article
Subjects: Employment
High grade gliomas
Young adults
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