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Title: APOE ɛ4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke.
Austin Authors: Werden, Emilio ;Khlif, Mohamed Salah;Bird, Laura J;Cumming, Toby;Bradshaw, Jennifer;Khan, Wasim;Pase, Matthew;Restrepo, Carolina;Veldsman, Michele;Egorova, Natalia;Patel, Sheila K ;Gottlieb, Elie;Brodtmann, Amy 
Affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK
Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia
Austin Health, Heidelberg, Victoria, Australia
Eastern Clinical Research Unit, Box Hill Hospital, Melbourne, Victoria, Australia
Issue Date: 29-Jul-2019 2019
Publication information: Journal of Alzheimer's disease : JAD 2019; 71(1): 245-259
Abstract: The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear. We compared cognition and medial temporal lobe volumes in APOEɛ4 carriers and non-carriers in the first year after ischemic stroke. We sampled 20 APOEɛ4 carriers and 20 non-carriers from a larger cohort of 135 ischemic stroke participants in the longitudinal CANVAS study. Participants were matched on a range of demographic and stroke characteristics. We used linear mixed-effect models to compare cognitive domain z-scores (attention, processing speed, executive function, verbal and visual memory, language, visuospatial function) and regional medial temporal lobe volumes (hippocampal, entorhinal cortex) between groups at each time-point (three, 12-months post-stroke), and within groups across time-points. APOE gene single nucleotide polymorphisms (SNPs; rs7412, rs429358) were genotyped on venous blood. APOEɛ4 carriers and non-carriers did not differ on any demographic, clinical, or stroke variable. Carriers performed worse than non-carriers in verbal memory at three months post-stroke (p = 0.046), but were better in executive function at 12 months (p = 0.035). Carriers demonstrated a significant improvement in verbal memory (p = 0.012) and executive function (p = 0.015) between time-points. Non-carriers demonstrated a significant improvement in visual memory (p = 0.0005). Carriers had smaller bilateral entorhinal cortex volumes (p <  0.05), and larger-right-sided and contralesional hippocampal volumes, at both time-points (p <  0.05). APOE ɛ4 is associated with delayed recovery of verbal memory function and reduced entorhinal cortex volumes in the first year after ischemic stroke.
DOI: 10.3233/JAD-190566
Journal: Journal of Alzheimer's disease : JAD
PubMed URL: 31381519
Type: Journal Article
Subjects: Apolipoproteins E
magnetic resonance imaging
Appears in Collections:Journal articles

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