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Title: Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring.
Austin Authors: Nahavandi, Sofia;Price, Sarah A ;Sumithran, Priya ;Ekinci, Elif Ilhan
Affiliation: Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
The Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia
Issue Date: 15-Jun-2019
Publication information: World journal of diabetes 2019; 10(6): 333-340
Abstract: Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines.
DOI: 10.4239/wjd.v10.i6.333
ORCID: 0000-0001-7722-3171
Journal: World journal of diabetes
PubMed URL: 31231456
ISSN: 1948-9358
Type: Journal Article
Subjects: Biomarkers
Gestational diabetes mellitus
Large for gestational age
Appears in Collections:Journal articles

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