Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20774
Title: The Structural Biology of Bcl-xL.
Austin Authors: Lee, Erinna F;Fairlie, W Douglas
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia
Issue Date: 7-May-2019
metadata.dc.date: 2019-05-07
Publication information: International journal of molecular sciences 2019; 20(9): E2234
Abstract: Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-xL. The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members. Subsequent structures of Bcl-xL complexes with pro-apoptotic ligands demonstrated the general features of all pro-survival:pro-apoptotic complexes. Structural studies involving Bcl-xL were also the basis for the discovery of the first small-molecule pro-survival protein inhibitors, leading ultimately to the development of a new class of drugs now successfully used for cancer treatment in the clinic. This article will review our current knowledge of the structural biology of Bcl-xL and how this has impacted our understanding of the molecular details of the intrinsic apoptotic pathway.
URI: http://ahro.austin.org.au/austinjspui/handle/1/20774
DOI: 10.3390/ijms20092234
ORCID: 0000-0003-1255-9808
0000-0002-2498-1160
PubMed URL: 31067648
Type: Journal Article
Subjects: BH3 domain
BH3-mimetic
BH3-only
Bcl-2
Bcl-xL
apoptosis
pro-survival
structural biology
Appears in Collections:Journal articles

Show full item record

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.