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https://ahro.austin.org.au/austinjspui/handle/1/20774
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DC Field | Value | Language |
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dc.contributor.author | Lee, Erinna F | - |
dc.contributor.author | Fairlie, W Douglas | - |
dc.date | 2019-05-07 | - |
dc.date.accessioned | 2019-05-17T00:24:42Z | - |
dc.date.available | 2019-05-17T00:24:42Z | - |
dc.date.issued | 2019-05-07 | - |
dc.identifier.citation | International journal of molecular sciences 2019; 20(9): E2234 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/20774 | - |
dc.description.abstract | Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-xL. The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members. Subsequent structures of Bcl-xL complexes with pro-apoptotic ligands demonstrated the general features of all pro-survival:pro-apoptotic complexes. Structural studies involving Bcl-xL were also the basis for the discovery of the first small-molecule pro-survival protein inhibitors, leading ultimately to the development of a new class of drugs now successfully used for cancer treatment in the clinic. This article will review our current knowledge of the structural biology of Bcl-xL and how this has impacted our understanding of the molecular details of the intrinsic apoptotic pathway. | - |
dc.language.iso | eng | - |
dc.subject | BH3 domain | - |
dc.subject | BH3-mimetic | - |
dc.subject | BH3-only | - |
dc.subject | Bcl-2 | - |
dc.subject | Bcl-xL | - |
dc.subject | apoptosis | - |
dc.subject | pro-survival | - |
dc.subject | structural biology | - |
dc.title | The Structural Biology of Bcl-xL. | - |
dc.type | Journal Article | - |
dc.identifier.journaltitle | International journal of molecular sciences | - |
dc.identifier.affiliation | Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia | en |
dc.identifier.doi | 10.3390/ijms20092234 | - |
dc.identifier.orcid | 0000-0003-1255-9808 | - |
dc.identifier.orcid | 0000-0002-2498-1160 | - |
dc.identifier.pubmedid | 31067648 | - |
dc.type.austin | Journal Article | - |
dc.type.austin | Review | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Journal articles |
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