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|Title:||Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes.||Austin Authors:||MacIsaac, Richard J;Farag, Matthew ;Obeyesekere, Varuni;Clarke, Michele V;Boston, Ray;Ward, Glenn M;Jerums, George ;Ekinci, Elif I||Affiliation:||Department of Medicine, University of Melbourne, Victoria, Australia
Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne
Clinical Chemistry, St Vincent's Hospital Melbourne
Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne..
Endocrine Centre, Austin Health, Heidelberg, Victoria, Australia
Menzies School of Health Sciences
|Issue Date:||15-Apr-2019||metadata.dc.date:||2019-04-15||Publication information:||Journal of diabetes investigation 2019; 10(6): 1537-1542||Abstract:||The relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1.73m2 , p<0.001) over an eight year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n=17). In a multi-level mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z=-4.31, p<0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however the factors driving this increase and the possible pathological role that sTNFR1 plays in progressive DKD remains to be determined. This article is protected by copyright. All rights reserved.||URI:||http://ahro.austin.org.au/austinjspui/handle/1/20722||DOI:||10.1111/jdi.13061||ORCID:||0000-0003-2372-395X
|PubMed URL:||30989829||Type:||Journal Article||Subjects:||Diabetic kidney disease
|Appears in Collections:||Journal articles|
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