Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes.

Abstract

The relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1.73m2 , p<0.001) over an eight year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n=17). In a multi-level mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z=-4.31, p<0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however the factors driving this increase and the possible pathological role that sTNFR1 plays in progressive DKD remains to be determined. This article is protected by copyright. All rights reserved.