Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/20722
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | MacIsaac, Richard J | - |
dc.contributor.author | Farag, Matthew | - |
dc.contributor.author | Obeyesekere, Varuni | - |
dc.contributor.author | Clarke, Michele V | - |
dc.contributor.author | Boston, Ray | - |
dc.contributor.author | Ward, Glenn M | - |
dc.contributor.author | Jerums, George | - |
dc.contributor.author | Ekinci, Elif I | - |
dc.date | 2019-04-15 | - |
dc.date.accessioned | 2019-04-30T23:55:28Z | - |
dc.date.available | 2019-04-30T23:55:28Z | - |
dc.date.issued | 2019-04-15 | - |
dc.identifier.citation | Journal of Diabetes Investigation 2019; 10(6): 1537-1542 | en_US |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/20722 | - |
dc.description.abstract | The relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1.73m2 , p<0.001) over an eight year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n=17). In a multi-level mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z=-4.31, p<0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however the factors driving this increase and the possible pathological role that sTNFR1 plays in progressive DKD remains to be determined. This article is protected by copyright. All rights reserved. | en_US |
dc.language.iso | eng | - |
dc.subject | Diabetic kidney disease | en_US |
dc.subject | GFR | en_US |
dc.subject | nephropathy | en_US |
dc.subject | sTNFR1 | en_US |
dc.title | Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Journal of Diabetes Investigation | en_US |
dc.identifier.affiliation | Department of Medicine, University of Melbourne, Victoria, Australia | en_US |
dc.identifier.affiliation | Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne | en_US |
dc.identifier.affiliation | Clinical Chemistry, St Vincent's Hospital Melbourne | en_US |
dc.identifier.affiliation | Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne.. | en_US |
dc.identifier.affiliation | Menzies School of Health Sciences | en_US |
dc.identifier.affiliation | Endocrinology | en_US |
dc.identifier.doi | 10.1111/jdi.13061 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0001-8058-6977 | en_US |
dc.identifier.orcid | 0000-0003-2372-395X | en_US |
dc.identifier.pubmedid | 30989829 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Ekinci, Elif I | |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Endocrinology | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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