Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20722
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dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorFarag, Matthew-
dc.contributor.authorObeyesekere, Varuni-
dc.contributor.authorClarke, Michele V-
dc.contributor.authorBoston, Ray-
dc.contributor.authorWard, Glenn M-
dc.contributor.authorJerums, George-
dc.contributor.authorEkinci, Elif I-
dc.date2019-04-15-
dc.date.accessioned2019-04-30T23:55:28Z-
dc.date.available2019-04-30T23:55:28Z-
dc.date.issued2019-04-15-
dc.identifier.citationJournal of Diabetes Investigation 2019; 10(6): 1537-1542en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20722-
dc.description.abstractThe relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1.73m2 , p<0.001) over an eight year period. In contrast, there were no significant changes in soluble TNFR1 levels in patients with stable renal function (n=17). In a multi-level mixed effects regression model, changes in soluble TNFR1 levels were found to be independently associated with eGFR decline (Z=-4.31, p<0.001). An early decline in eGFR is associated with an increase in soluble TNFR levels; however the factors driving this increase and the possible pathological role that sTNFR1 plays in progressive DKD remains to be determined. This article is protected by copyright. All rights reserved.en_US
dc.language.isoeng-
dc.subjectDiabetic kidney diseaseen_US
dc.subjectGFRen_US
dc.subjectnephropathyen_US
dc.subjectsTNFR1en_US
dc.titleChanges in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Diabetes Investigationen_US
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Endocrinology & Diabetes, St Vincent's Hospital Melbourneen_US
dc.identifier.affiliationClinical Chemistry, St Vincent's Hospital Melbourneen_US
dc.identifier.affiliationDepartment of Endocrinology & Diabetes, St Vincent's Hospital Melbourne..en_US
dc.identifier.affiliationMenzies School of Health Sciencesen_US
dc.identifier.affiliationEndocrinologyen_US
dc.identifier.doi10.1111/jdi.13061en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8058-6977en_US
dc.identifier.orcid0000-0003-2372-395Xen_US
dc.identifier.pubmedid30989829-
dc.type.austinJournal Article-
local.name.researcherEkinci, Elif I
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptUrology-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
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