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Title: Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study.
Austin Authors: Lloyd-Donald, Patryck ;Churilov, Leonid ;Zia, Faizan;Bellomo, Rinaldo ;Hart, Graeme K ;McCall, Peter R ;Mårtensson, Johan;Glassford, Neil;Weinberg, Laurence 
Affiliation: Melbourne Brain Centre, Heidelberg, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital, Solna, Sweden
Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77, Stockholm, Sweden
Issue Date: 30-Mar-2019 2019
Publication information: BMC anesthesiology 2019; 19(1): 45
Abstract: TEG6S® and TEG5000® (Haemonetics Corp, USA) are haemostasis analysers that measure viscoelasticity properties of whole blood. Both use different mechanisms to assess similar components of the coagulation process. The aim of this study was to assess agreement and interchangeability between the TEG6S and TEG5000 analysers. 3.5 mL whole blood was collected from 25 adult patients in a tertiary intensive care unit (ICU). Analysis was performed using TEG6S and TEG5000 haemostatic platforms. Agreement between platforms was measured using Lin's concordance coefficient (Lin's CC), further validated using intraclass correlation coefficients and reduced major axis regression (RMAR). Sixteen (64%) patients were male; mean (range) age: 59yo (23-86). TEG6S and TEG5000 systems were broadly interchangeable. The majority of TEG variables demonstrated almost perfect or substantial agreement and minimal proportional bias (maximum amplitude demonstrated a fixed bias). LY30%, however, demonstrated poor agreement and a proportional bias. Lin's CC coefficients (95% CI, RMAR slope, intercept) between TEG6S and TEG5000 variables were: R time: 0.78 (0.64-0.92, 0.76, 0.92); K time: 0.82 (0.69-0.94, 1.30, - 0.93); alpha angle: 0.79 (0.64-0.95, 1.04, - 1.43); maximum amplitude (MA): 0.90 (0.83-0.96, 0.99, - 5.0); LY30%: 0.34 (0.1-0.58, 0.43, 0.04). Adult patients with critical illness demonstrate almost perfect agreement in the R time and MA, substantial agreement in K time and alpha angle, but poor agreement in LY30%, as measured by the TEG6S and TEG5000 analysers. With the exception of LY30%, the TEG6S and TEG5000 platforms appear interchangeable. This has important implications for use in clinical practice and multi-site research programs. ANZCRT number: 12617000062325 , registered 12/Jan17. Retrospectively registered.
DOI: 10.1186/s12871-019-0717-7
ORCID: 0000-0001-7403-7680
PubMed URL: 30927909
Type: Journal Article
Subjects: Coagulation
Appears in Collections:Journal articles

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