Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.

2019-04

Porter, Tenielle

Burnham, Samantha C

Milicic, Lidija

Savage, Greg

Maruff, Paul

Lim, Yen Ying

Ames, David

Masters, Colin L

Martins, Ralph N

Rainey-Smith, Stephanie R

Rowe, Christopher C

Salvado, Olivier

Groth, David

Verdile, Giuseppe

Villemagne, Victor L

Laws, Simon M

Alzheimer's disease

Cognition

Episodic memory

KL-VS

Klotho

Preclinical

amyloid-β

Journal Article

0000-0003-3910-2453

10.1016/j.neurobiolaging.2018.12.014

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.

link

Neurobiology of aging 2019; 76: 162-165

Neurobiology of aging