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https://ahro.austin.org.au/austinjspui/handle/1/20343| Title: | Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease. | Austin Authors: | Porter, Tenielle;Burnham, Samantha C;Milicic, Lidija;Savage, Greg;Maruff, Paul;Lim, Yen Ying;Ames, David;Masters, Colin L ;Martins, Ralph N;Rainey-Smith, Stephanie R;Rowe, Christopher C ;Salvado, Olivier;Groth, David;Verdile, Giuseppe;Villemagne, Victor L ;Laws, Simon M | Affiliation: | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia National Ageing Research Institute, Parkville, Victoria, Australia Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Psychology, ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, North Ryde, NSW, Australia Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia CSIRO Health and Biosecurity, Parkville, Victoria, Australia CogState Ltd., Melbourne, Victoria, Australia Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia |
Issue Date: | Apr-2019 | Date: | 2019-01-06 | Publication information: | Neurobiology of aging 2019; 76: 162-165 | Abstract: | The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/20343 | DOI: | 10.1016/j.neurobiolaging.2018.12.014 | ORCID: | 0000-0003-3910-2453 | Journal: | Neurobiology of aging | PubMed URL: | 30716541 | Type: | Journal Article | Subjects: | Alzheimer's disease Cognition Episodic memory KL-VS Klotho Preclinical amyloid-β |
| Appears in Collections: | Journal articles |
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