Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/20343
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Porter, Tenielle | - |
dc.contributor.author | Burnham, Samantha C | - |
dc.contributor.author | Milicic, Lidija | - |
dc.contributor.author | Savage, Greg | - |
dc.contributor.author | Maruff, Paul | - |
dc.contributor.author | Lim, Yen Ying | - |
dc.contributor.author | Ames, David | - |
dc.contributor.author | Masters, Colin L | - |
dc.contributor.author | Martins, Ralph N | - |
dc.contributor.author | Rainey-Smith, Stephanie R | - |
dc.contributor.author | Rowe, Christopher C | - |
dc.contributor.author | Salvado, Olivier | - |
dc.contributor.author | Groth, David | - |
dc.contributor.author | Verdile, Giuseppe | - |
dc.contributor.author | Villemagne, Victor L | - |
dc.contributor.author | Laws, Simon M | - |
dc.date | 2019-01-06 | - |
dc.date.accessioned | 2019-03-04T22:04:18Z | - |
dc.date.available | 2019-03-04T22:04:18Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | Neurobiology of aging 2019; 76: 162-165 | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/20343 | - |
dc.description.abstract | The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD. | en |
dc.language.iso | eng | - |
dc.subject | Alzheimer's disease | en |
dc.subject | Cognition | en |
dc.subject | Episodic memory | en |
dc.subject | KL-VS | en |
dc.subject | Klotho | en |
dc.subject | Preclinical | en |
dc.subject | amyloid-β | en |
dc.title | Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | Neurobiology of aging | en |
dc.identifier.affiliation | Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | National Ageing Research Institute, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia | en |
dc.identifier.affiliation | School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia | en |
dc.identifier.affiliation | CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia | en |
dc.identifier.affiliation | Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia | en |
dc.identifier.affiliation | The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | Department of Psychology, ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, North Ryde, NSW, Australia | en |
dc.identifier.affiliation | Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia | en |
dc.identifier.affiliation | Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia | en |
dc.identifier.affiliation | CSIRO Health and Biosecurity, Parkville, Victoria, Australia | en |
dc.identifier.affiliation | CogState Ltd., Melbourne, Victoria, Australia | en |
dc.identifier.affiliation | Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia | en |
dc.identifier.doi | 10.1016/j.neurobiolaging.2018.12.014 | en |
dc.type.content | Text | en |
dc.identifier.orcid | 0000-0003-3910-2453 | en |
dc.identifier.pubmedid | 30716541 | - |
dc.type.austin | Journal Article | - |
local.name.researcher | Masters, Colin L | |
item.languageiso639-1 | en | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | The Florey Institute of Neuroscience and Mental Health | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
crisitem.author.dept | Molecular Imaging and Therapy | - |
Appears in Collections: | Journal articles |
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