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Title: Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.
Austin Authors: Bitker, Laurent;Burrell, Louise M 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: Apr-2019
Date: 2019-01-28
Publication information: Critical care clinics 2019; 35(2): 213-227
Abstract: Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively.
DOI: 10.1016/j.ccc.2018.11.002
Journal: Critical care clinics
PubMed URL: 30784605
Type: Journal Article
Subjects: Acute kidney injury
Acute respiratory distress syndrome
Angiotensin-converting enzyme
Septic shock
Appears in Collections:Journal articles

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