| Title |
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Classic and Nonclassic Renin-Angiotensin Systems in the Critically Ill. |
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| Author(s) |
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| Subject |
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Acute respiratory distress syndrome |
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Angiotensin-converting enzyme |
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| Type of document |
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| DOI |
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10.1016/j.ccc.2018.11.002 |
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| Abstract |
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Classic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively. |
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| Link |
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| Citation |
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Critical care clinics 2019; 35(2): 213-227 |
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| Jornal Title |
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