Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/20298
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dc.contributor.authorBitker, Laurent-
dc.contributor.authorBurrell, Louise Men
dc.date2019-01-28-
dc.date.accessioned2019-03-04T22:04:14Z-
dc.date.available2019-03-04T22:04:14Z-
dc.date.issued2019-04-
dc.identifier.citationCritical care clinics 2019; 35(2): 213-227-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/20298-
dc.description.abstractClassic and nonclassic renin-angiotensin systems (RAS) are 2 sides of an ubiquitous endocrine/paracrine cascade regulating blood pressure and homeostasis. Angiotensin II and angiotensin-converting enzyme (ACE) levels are associated with severity of disease in the critically ill, and are central to the physiology and the pathogenesis of circulatory shock. Angiotensin (1-7) and ACE2 act as an endogenous counterregulatory arm to the angiotensin II/ACE axis. The tissue-based RAS has paracrine effects dissociated from those of the circulating RAS. Exogenous angiotensin II or ACE2 may improve the outcome of septic shock and acute respiratory distress syndrome, respectively.-
dc.language.isoeng-
dc.subjectAcute kidney injury-
dc.subjectAcute respiratory distress syndrome-
dc.subjectAngiotensin-
dc.subjectAngiotensin-converting enzyme-
dc.subjectInflammation-
dc.subjectRenin-
dc.subjectSepsis-
dc.subjectSeptic shock-
dc.titleClassic and Nonclassic Renin-Angiotensin Systems in the Critically Ill.-
dc.typeJournal Article-
dc.identifier.journaltitleCritical care clinics-
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1016/j.ccc.2018.11.002-
dc.identifier.pubmedid30784605-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherBurrell, Louise M
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
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