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Title: Hormonal Therapy in Organ Donors.
Austin Authors: Opdam, Helen I 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Apr-2019 2019-01-24
Publication information: Critical care clinics 2019; 35(2): 389-405
Abstract: Optimal supportive treatment of brain dead potential organ donors maximizes donation and transplant outcomes. Brain death is associated with activation of inflammatory pathways and loss of autoregulatory brain functions that may include hypothalamic-pituitary dysfunction. As well as general supportive care, specific treatment to counter the common sequelae of brain death such as hypotension, hypothermia, and diabetes insipidus is required. In addition, the provision of specific hormonal therapy (thyroid hormone, vasopressin, and steroids) has been proposed but is controversial due to lack of high level evidence to support its efficacy.
DOI: 10.1016/j.ccc.2018.11.013
Journal: Critical care clinics
PubMed URL: 30784617
Type: Journal Article
Subjects: Brain death
Donor management
Hormone therapy
Organ donation
Thyroid hormone
Appears in Collections:Journal articles

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