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Title: Transfer of donor anti-HLA antibody expression to multiple transplant recipients- a potential variant of the Passenger Lymphocyte Syndrome?
Austin Authors: Kummrow, Megan;Hiho, Steven;Hudson, Fiona;Cantwell, Linda;Mulley, William R;D'Orsogna, Lloyd;Testro, Adam G ;Pavlovic, Julie ;MacDonald, Peter;Sullivan, Lucy C;Snell, Gregory I;Westall, Glen P
Affiliation: Victorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australia
Department of Clinical Immunology, Fiona Stanley Hospital, Perth, Australia
Department of Nephrology, Monash Medical Centre, Clayton, Australia
Lung Transplant Service, Alfred Hospital, Melbourne, Australia
Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Heart Transplant Service, St Vincent's Hospital, Sydney, Australia
Victorian Liver Transplant Unit
Issue Date: 17-Jan-2019
Date: 2019-02-13
Publication information: American Journal of Transplantation 2019; 19(5): 1577-1581
Abstract: Antibody mediated rejection (AMR), whereby transplant recipient B cells and/or plasma cells produce allo-reactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early post-transplant co-existence of a shared anti-HLA antibody profile in five solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the Passenger Lymphocyte Syndrome. These findings have important implications for the consideration of all post-transplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients. This article is protected by copyright. All rights reserved.
DOI: 10.1111/ajt.15262
Journal: American Journal of Transplantation
PubMed URL: 30653828
Type: Journal Article
Appears in Collections:Journal articles

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