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dc.contributor.authorKummrow, Megan-
dc.contributor.authorHiho, Steven-
dc.contributor.authorHudson, Fiona-
dc.contributor.authorCantwell, Linda-
dc.contributor.authorMulley, William R-
dc.contributor.authorD'Orsogna, Lloyd-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorPavlovic, Julie-
dc.contributor.authorMacDonald, Peter-
dc.contributor.authorSullivan, Lucy C-
dc.contributor.authorSnell, Gregory I-
dc.contributor.authorWestall, Glen P-
dc.identifier.citationAmerican Journal of Transplantation 2019; 19(5): 1577-1581en
dc.description.abstractAntibody mediated rejection (AMR), whereby transplant recipient B cells and/or plasma cells produce allo-reactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early post-transplant co-existence of a shared anti-HLA antibody profile in five solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the Passenger Lymphocyte Syndrome. These findings have important implications for the consideration of all post-transplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients. This article is protected by copyright. All rights reserved.en
dc.titleTransfer of donor anti-HLA antibody expression to multiple transplant recipients- a potential variant of the Passenger Lymphocyte Syndrome?en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Transplantationen
dc.identifier.affiliationVictorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Clinical Immunology, Fiona Stanley Hospital, Perth, Australiaen
dc.identifier.affiliationDepartment of Nephrology, Monash Medical Centre, Clayton, Australiaen
dc.identifier.affiliationLung Transplant Service, Alfred Hospital, Melbourne, Australiaen
dc.identifier.affiliationDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australiaen
dc.identifier.affiliationHeart Transplant Service, St Vincent's Hospital, Sydney, Australiaen
dc.identifier.affiliationVictorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australiaen
dc.type.austinCase Reports-
Appears in Collections:Journal articles
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