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dc.contributor.authorKummrow, Megan-
dc.contributor.authorHiho, Steven-
dc.contributor.authorHudson, Fiona-
dc.contributor.authorCantwell, Linda-
dc.contributor.authorMulley, William R-
dc.contributor.authorD'Orsogna, Lloyd-
dc.contributor.authorTestro, Adam G-
dc.contributor.authorPavlovic, Julie-
dc.contributor.authorMacDonald, Peter-
dc.contributor.authorSullivan, Lucy C-
dc.contributor.authorSnell, Gregory I-
dc.contributor.authorWestall, Glen P-
dc.identifier.citationAmerican Journal of Transplantation 2019; 19(5): 1577-1581en_US
dc.description.abstractAntibody mediated rejection (AMR), whereby transplant recipient B cells and/or plasma cells produce allo-reactive anti-human leukocyte antigen (HLA) antibodies, negatively influences transplant outcomes and is a major contributor to graft loss. An early humoral immune response is suggested by the production of anti-HLA donor-specific antibodies (DSA) that can be measured using solid phase assays. We report the early post-transplant co-existence of a shared anti-HLA antibody profile in five solid organ transplant recipients who received organs from the same donor. Retrospective analysis of the donor's serum confirmed the presence of the same anti-HLA profile, suggesting the transfer of donor-derived anti-HLA antibodies, or the cells that produce them, to multiple solid organ transplant recipients. The time frame and extent of transfer suggest a novel variant of the Passenger Lymphocyte Syndrome. These findings have important implications for the consideration of all post-transplant antibody measurements, particularly the interpretation of non-DSAs in the sera of transplant recipients. This article is protected by copyright. All rights reserved.en_US
dc.titleTransfer of donor anti-HLA antibody expression to multiple transplant recipients- a potential variant of the Passenger Lymphocyte Syndrome?en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAmerican Journal of Transplantationen_US
dc.identifier.affiliationVictorian Transplantation and Immunogenetics Service, Australian Red Cross Blood Service, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Clinical Immunology, Fiona Stanley Hospital, Perth, Australiaen_US
dc.identifier.affiliationDepartment of Nephrology, Monash Medical Centre, Clayton, Australiaen_US
dc.identifier.affiliationLung Transplant Service, Alfred Hospital, Melbourne, Australiaen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, Melbourne, Australiaen_US
dc.identifier.affiliationHeart Transplant Service, St Vincent's Hospital, Sydney, Australiaen_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.type.austinCase Reports-, Julie
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone- Liver Transplant Unit- and Hepatology- Liver Transplant Unit-
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