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Title: The impact of sample type and procedural attributes on relative acceptability of different colorectal cancer screening regimens.
Austin Authors: Osborne, Joanne M;Flight, Ingrid;Wilson, Carlene J ;Chen, Gang;Ratcliffe, Julie;Young, Graeme P
Affiliation: Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, SA, Australia
Bowel Health Service, Repatriation General Hospital, Daw Park, SA, Australia
School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 18-Sep-2018 2018-09-18
Publication information: Patient preference and adherence 2018; 12: 1825-1836
Abstract: In Australia and other countries, participation in colorectal cancer (CRC) screening using fecal occult blood testing is low. Previous research suggests that fecal sampling induces disgust, so approaches not involving feces may increase participation. This study aimed to determine population preferences for CRC screening tests that utilize different sample collections (stool, blood, and saliva) and the extent to which specific attributes (convenience, performance, and cost) impact this preference. People aged 50-74 years completed a survey. Preference for screening for CRC through stool, blood, and saliva was judged through ranking of preference and attributes critical to preference and confirmed via a discrete choice experiment (DCE) where test attributes were described as varying by performance, cost, and sample type. Participants also completed a measure of aversion to sample type. A total of 1,282 people participated in the survey. The DCE and ranking exercise confirmed that all test attributes had a statistically significant impact on respondents' preferences (P < 0.001). Blood and saliva were equally preferred over stool; however, test performance was the most influential attribute. In multivariable analyses, those who preferred blood to stool collection exhibited higher aversion to fecal (OR = 1.17; P ≤ 0.001) and saliva (OR = 1.06; P ≤ 0.05) sampling and perceived that they had less time for home sample collection (OR = 0.72, P ≤ 0.001). Those who preferred saliva to stool had higher aversion to fecal (OR = 1.15; P ≤ 0.001) and blood (OR = 1.06, P ≤ 0.01) sampling and less time for home sample collection (OR = 0.81, P ≤ 0.5). Aversion to sample type and perceived inconvenience of sample collection are significant drivers of screening preference. While blood and saliva sampling were the most preferred methods, test performance was the most important attribute of a screening test, regardless of sample type. Efforts to increase CRC screening participation should focus on a test, or combination of tests, that combines the attributes of high performance, low aversion, and convenience of use.
DOI: 10.2147/PPA.S172143
ORCID: 0000-0002-1883-4690
PubMed URL: 30271126
ISSN: 1177-889X
Type: Journal Article
Subjects: Australia
discrete choice experiment
home stool test
quantitative study
Appears in Collections:Journal articles

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