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Title: Physiological basis behind ergogenic effects of anabolic androgens.
Austin Authors: Cheung, Ada S ;Grossmann, Mathis 
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 15-Mar-2018 2017-01-31
Publication information: Molecular and cellular endocrinology 2018; 464: 14-20
Abstract: Anabolic androgenic steroids (AAS) are widely abused by the sporting community. Demonstrating performance enhancing effects of AAS in rigorous scientific studies is fraught with difficulty. In controlled studies, AAS have consistently been reported to increase muscle mass and strength. The clinical evidence that these anabolic effects are independent of, and additive to exercise are supported by preclinical studies suggesting that AAS and exercise affect muscle by overlapping, yet distinct mechanisms. AAS may also improve performance by their actions on other organ systems, such as the vasculature, and the erythropoietic and central nervous system, although this evidence is less strong. While most of the actions of AAS are thought to be mediated via classical androgen receptor-mediated genomic signalling, AAS may also produce rapid effects via non-genomic mechanisms.
DOI: 10.1016/j.mce.2017.01.047
ORCID: 0000-0001-5257-5525
PubMed URL: 28159654
Type: Journal Article
Subjects: Anabolic androgenic steroids
Androgen receptor signalling
Appears in Collections:Journal articles

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