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Title: Contralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas.
Austin Authors: Palesi, Fulvia;De Rinaldis, Andrea;Castellazzi, Gloria;Calamante, Fernando;Muhlert, Nils;Chard, Declan;Tournier, J Donald;Magenes, Giovanni;D'Angelo, Egidio;Gandini Wheeler-Kingshott, Claudia A M
Affiliation: Brain MRI 3T Research Center, C. Mondino National Neurological Institute, Pavia, PV, Italy
Florey Department of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia
NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom
School of Psychological Sciences, University of Manchester, Manchester, United Kingdom
Department of Biomedical Engineering, King's College London, London, UK
Centre for the Developing Brain, King's College London, London, UK
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
Department of Physics, University of Pavia, Pavia, PV, Italy
Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, PV, Italy
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
National Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, PV, Italy
Issue Date: 9-Oct-2017 2017
Publication information: Scientific Reports 2017; 7(1): 12841
Abstract: Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and include the cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) pathways. CTC and CPC characterization in humans in vivo is still challenging. Here advanced tractography was combined with quantitative indices to compare CPC to CTC pathways in healthy subjects. Differently to previous studies, our findings reveal that cerebellar cognitive areas are reached by the largest proportion of the reconstructed CPC, supporting the hypothesis that a CTC-CPC loop provides a substrate for cerebro-cerebellar communication during cognitive processing. Amongst the cerebral areas identified using in vivo tractography, in addition to the cerebral motor cortex, major portions of CPC streamlines leave the prefrontal and temporal cortices. These findings are useful since provide MRI-based indications of possible subtending connectivity and, if confirmed, they are going to be a milestone for instructing computational models of brain function. These results, together with further multi-modal investigations, are warranted to provide important cues on how the cerebro-cerebellar loops operate and on how pathologies involving cerebro-cerebellar connectivity are generated.
DOI: 10.1038/s41598-017-13079-8
ORCID: 0000-0001-5027-8770
PubMed URL: 28993670
Type: Journal Article
Appears in Collections:Journal articles

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