Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18408
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dc.contributor.authorPalesi, Fulvia-
dc.contributor.authorDe Rinaldis, Andrea-
dc.contributor.authorCastellazzi, Gloria-
dc.contributor.authorCalamante, Fernando-
dc.contributor.authorMuhlert, Nils-
dc.contributor.authorChard, Declan-
dc.contributor.authorTournier, J Donald-
dc.contributor.authorMagenes, Giovanni-
dc.contributor.authorD'Angelo, Egidio-
dc.contributor.authorGandini Wheeler-Kingshott, Claudia A M-
dc.date2017-
dc.date.accessioned2018-08-30T05:58:49Z-
dc.date.available2018-08-30T05:58:49Z-
dc.date.issued2017-10-09-
dc.identifier.citationScientific Reports 2017; 7(1): 12841-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18408-
dc.description.abstractCerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and include the cerebello-thalamo-cortical (CTC) and cortico-ponto-cerebellar (CPC) pathways. CTC and CPC characterization in humans in vivo is still challenging. Here advanced tractography was combined with quantitative indices to compare CPC to CTC pathways in healthy subjects. Differently to previous studies, our findings reveal that cerebellar cognitive areas are reached by the largest proportion of the reconstructed CPC, supporting the hypothesis that a CTC-CPC loop provides a substrate for cerebro-cerebellar communication during cognitive processing. Amongst the cerebral areas identified using in vivo tractography, in addition to the cerebral motor cortex, major portions of CPC streamlines leave the prefrontal and temporal cortices. These findings are useful since provide MRI-based indications of possible subtending connectivity and, if confirmed, they are going to be a milestone for instructing computational models of brain function. These results, together with further multi-modal investigations, are warranted to provide important cues on how the cerebro-cerebellar loops operate and on how pathologies involving cerebro-cerebellar connectivity are generated.-
dc.language.isoeng-
dc.titleContralateral cortico-ponto-cerebellar pathways reconstruction in humans in vivo: implications for reciprocal cerebro-cerebellar structural connectivity in motor and non-motor areas.-
dc.typeJournal Article-
dc.identifier.journaltitleScientific Reports-
dc.identifier.affiliationBrain MRI 3T Research Center, C. Mondino National Neurological Institute, Pavia, PV, Italyen
dc.identifier.affiliationFlorey Department of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdomen
dc.identifier.affiliationSchool of Psychological Sciences, University of Manchester, Manchester, United Kingdomen
dc.identifier.affiliationDepartment of Biomedical Engineering, King's College London, London, UKen
dc.identifier.affiliationCentre for the Developing Brain, King's College London, London, UKen
dc.identifier.affiliationDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italyen
dc.identifier.affiliationDepartment of Physics, University of Pavia, Pavia, PV, Italy-
dc.identifier.affiliationBrain Connectivity Center, C. Mondino National Neurological Institute, Pavia, PV, Italyen
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, United Kingdom.-
dc.identifier.affiliationDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, PV, Italy-
dc.identifier.doi10.1038/s41598-017-13079-8-
dc.identifier.orcid0000-0001-5027-8770en
dc.identifier.orcid0000-0002-7550-3142en
dc.identifier.pubmedid28993670-
dc.type.austinJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
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