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Title: The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.
Austin Authors: Ward, Stephanie Alison;Storey, Elsdon;Woods, Robyn L;Hamilton, Garun S;Kawasaki, Ryo;Janke, Andrew L;Naughton, Matthew T;O'Donoghue, Fergal J ;Wolfe, Rory;Wong, Tien Y;Reid, Christopher M;Abhayaratna, Walter P;Stocks, Nigel;Trevaks, Ruth;Fitzgerald, Sharyn;Hodgson, Lauren A B;Robman, Liubov;Workman, Barbara;McNeil, John J
Affiliation: Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia
School of Clinical Sciences, Monash University, 246 Clayton Rd, Clayton, Vic 3168, Australia
Department of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australia
Duke-NUS Medical School, National University of Singapore, 8 College Rd, 169857, Singapore
Singapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore
Department of Neuroscience (Medicine), Monash University, The Alfred Hospital, Commercial Rd, Melbourne 3004, Australia
Institute for Breathing and Sleep
School of Public Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia
Department of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japan
Centre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australia
The Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australia
College of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australia
Discipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australia
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia
Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia
The ASPREE Study Group, Australia, USA
Austin Health
Issue Date: Jan-2018
Date: 2017-10-31
Publication information: Contemporary Clinical Trials 2018; 64: 101-111
Abstract: Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. ACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and Number NCT01038583.
DOI: 10.1016/j.cct.2017.10.016
ORCID: 0000-0001-5099-3184
Journal: Contemporary Clinical Trials
PubMed URL: 29097299
Type: Journal Article
Subjects: Brain Magnetic Resonance Imaging
Cognitive decline
Low-dose aspirin
Retinal vascular imaging
Sleep disordered breathing
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