Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18377
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dc.contributor.authorWard, Stephanie Alison-
dc.contributor.authorStorey, Elsdon-
dc.contributor.authorWoods, Robyn L-
dc.contributor.authorHamilton, Garun S-
dc.contributor.authorKawasaki, Ryo-
dc.contributor.authorJanke, Andrew L-
dc.contributor.authorNaughton, Matthew T-
dc.contributor.authorO'Donoghue, Fergal J-
dc.contributor.authorWolfe, Rory-
dc.contributor.authorWong, Tien Y-
dc.contributor.authorReid, Christopher M-
dc.contributor.authorAbhayaratna, Walter P-
dc.contributor.authorStocks, Nigel-
dc.contributor.authorTrevaks, Ruth-
dc.contributor.authorFitzgerald, Sharyn-
dc.contributor.authorHodgson, Lauren A B-
dc.contributor.authorRobman, Liubov-
dc.contributor.authorWorkman, Barbara-
dc.contributor.authorMcNeil, John J-
dc.date2017-10-31-
dc.date.accessioned2018-08-30T05:58:04Z-
dc.date.available2018-08-30T05:58:04Z-
dc.date.issued2018-01-
dc.identifier.citationContemporary Clinical Trials 2018; 64: 101-111en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18377-
dc.description.abstractSleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. ACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.en_US
dc.language.isoeng-
dc.subjectBrain Magnetic Resonance Imagingen_US
dc.subjectCognitive declineen_US
dc.subjectDementiaen_US
dc.subjectLow-dose aspirinen_US
dc.subjectRetinal vascular imagingen_US
dc.subjectSleep disordered breathingen_US
dc.titleThe Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleContemporary Clinical Trialsen_US
dc.identifier.affiliationFaculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Clinical Sciences, Monash University, 246 Clayton Rd, Clayton, Vic 3168, Australiaen_US
dc.identifier.affiliationDepartment of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australiaen_US
dc.identifier.affiliationDuke-NUS Medical School, National University of Singapore, 8 College Rd, 169857, Singaporeen_US
dc.identifier.affiliationSingapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singaporeen_US
dc.identifier.affiliationDepartment of Neuroscience (Medicine), Monash University, The Alfred Hospital, Commercial Rd, Melbourne 3004, Australiaen_US
dc.identifier.affiliationInstitute for Breathing and Sleepen_US
dc.identifier.affiliationSchool of Public Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australiaen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australiaen_US
dc.identifier.affiliationDepartment of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japanen_US
dc.identifier.affiliationCentre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australiaen_US
dc.identifier.affiliationThe Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australiaen_US
dc.identifier.affiliationCollege of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australiaen_US
dc.identifier.affiliationDiscipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australiaen_US
dc.identifier.affiliationCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australiaen_US
dc.identifier.affiliationMonash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australiaen_US
dc.identifier.affiliationThe ASPREE Study Group, Australia, USAen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.doi10.1016/j.cct.2017.10.016en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-5099-3184en_US
dc.identifier.pubmedid29097299-
dc.type.austinJournal Article-
local.name.researcherO'Donoghue, Fergal J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRespiratory and Sleep Medicine-
crisitem.author.deptInstitute for Breathing and Sleep-
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