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Title: White matter microstructure in anorexia nervosa.
Austin Authors: Phillipou, Andrea ;Carruthers, Sean P;Di Biase, Maria A;Zalesky, Andrew;Abel, Larry A A;Castle, David J;Gurvich, Caroline;Rossell, Susan L
Affiliation: Department of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia
Department of Psychiatry, The University of Melbourne, Melbourne, Australia
Department of Mental Health, Austin Health, Heidelberg, Victoria, Australia
Department of Mental Health, St Vincent's Hospital, Melbourne, Australia
Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia
Monash Alfred Psychiatry Research Centre, Monash University & The Alfred Hospital, Melbourne, Australia
Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard, Medical School, Massachusetts
Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
Issue Date: 2018 2018-07-02
Publication information: Human brain mapping 2018; 39(11): 4385-4392
Abstract: The neurobiological underpinnings of anorexia nervosa (AN) are unclear. White matter deficits have been described in the illness, but findings are inconsistent between studies. The aim of this study was to investigate differences in white matter microstructure in AN using diffusion-weighted imaging (DWI). It was hypothesised that people with AN, relative to a healthy control (HC) group, would show decreased functional anisotropy (FA) and increased mean diffusivity (MD) in the fornix and superior longitudinal fasciculus, consistent with previous literature. Analyses were conducted on 23 females with AN and 26 age- and gender-matched HCs using tract-based spatial statistics (TBSS). The results revealed widespread FA decreases and MD increases in the AN group. Our hypothesis was largely supported, although FA differences were not specifically found in the fornix. The findings suggest extensive differences in white matter structure in AN, which may contribute to AN pathophysiology.
DOI: 10.1002/hbm.24279
ORCID: 0000-0003-1009-6619
Journal: Human brain mapping
PubMed URL: 29964345
Type: Journal Article
Subjects: diffusion
eating disorder
fractional anisotropy
Magnetic Resonance Imaging
Appears in Collections:Journal articles

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