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dc.contributor.authorPhillipou, Andrea-
dc.contributor.authorCarruthers, Sean P-
dc.contributor.authorDi Biase, Maria A-
dc.contributor.authorZalesky, Andrew-
dc.contributor.authorAbel, Larry A A-
dc.contributor.authorCastle, David J-
dc.contributor.authorGurvich, Caroline-
dc.contributor.authorRossell, Susan L-
dc.identifier.citationHuman brain mapping 2018; 39(11): 4385-4392-
dc.description.abstractThe neurobiological underpinnings of anorexia nervosa (AN) are unclear. White matter deficits have been described in the illness, but findings are inconsistent between studies. The aim of this study was to investigate differences in white matter microstructure in AN using diffusion-weighted imaging (DWI). It was hypothesised that people with AN, relative to a healthy control (HC) group, would show decreased functional anisotropy (FA) and increased mean diffusivity (MD) in the fornix and superior longitudinal fasciculus, consistent with previous literature. Analyses were conducted on 23 females with AN and 26 age- and gender-matched HCs using tract-based spatial statistics (TBSS). The results revealed widespread FA decreases and MD increases in the AN group. Our hypothesis was largely supported, although FA differences were not specifically found in the fornix. The findings suggest extensive differences in white matter structure in AN, which may contribute to AN pathophysiology.-
dc.subjecteating disorder-
dc.subjectfractional anisotropy-
dc.subjectMagnetic Resonance Imaging-
dc.titleWhite matter microstructure in anorexia nervosa.-
dc.typeJournal Article-
dc.identifier.journaltitleHuman brain mapping-
dc.identifier.affiliationDepartment of Optometry & Vision Sciences, The University of Melbourne, Melbourne, Australia-
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Melbourne, Australia-
dc.identifier.affiliationDepartment of Mental Health, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationDepartment of Mental Health, St Vincent's Hospital, Melbourne, Australia-
dc.identifier.affiliationCentre for Mental Health, Swinburne University of Technology, Melbourne, Australia-
dc.identifier.affiliationMonash Alfred Psychiatry Research Centre, Monash University & The Alfred Hospital, Melbourne, Australia-
dc.identifier.affiliationPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard, Medical School, Massachusetts-
dc.identifier.affiliationMelbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia-
dc.type.austinJournal Article-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Health-
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