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Title: The relationship between anticipated response and subsequent experience of cancer treatment-related side effects: A meta-analysis comparing effects before and after treatment exposure.
Austin Authors: Fletcher, Chloe;Wilson, Carlene J ;Hutchinson, Amanda D;Grunfeld, Elizabeth Alice
Affiliation: Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, SA, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
School of Psychology and Public Health, La Trobe University, Bundoora, Victoria, Australia
School of Psychology, Social Work and Social Policy, University of South Australia, SA, Australia
Department of Psychological Sciences, Birkbeck College, University of London, London, UK
Issue Date: Jul-2018
Date: 2018-06-15
Publication information: Cancer treatment reviews 2018; 68: 86-93
Abstract: To review the evidence for a systematic relationship between cancer patients' pre-treatment expectations (anticipated side effects) and subsequent experience of treatment-related side effects, and to compare this relationship in patients with no prior treatment experience (cognitive expectations) and with some prior treatment experience (conditioned response). A total of 12,952 citations were identified through a comprehensive search of the literature published on or before November 2016 and screened against inclusion criteria. Studies were eligible if they included participants undergoing curative treatment for cancer, measured a treatment side effect, examined the relationship between anticipation and experience of side effects, and reported quantitative data. Thirty-one studies were included in the review and meta-analysis (total N = 5069). The side effects examined were nausea (anticipatory and post-treatment), vomiting, fatigue, pain, problems with concentration, and skin reactions. Meta-analyses indicated positive associations between anticipation and subsequent experience for all included side effects in patients with no prior treatment exposure (r = 0.153-0.431). Stronger associations were found for all included side effects in patients with previous treatment experience (r = 0.211-0.476), except for fatigue (r = 0.266) and pain (r = 0.235). No significant differences were found when overall effect sizes for patients with and without prior treatment exposure were compared for each side effect, except for anticipatory nausea (p = 0.012). These results may have implications for future interventions that target patients' expectations of cancer treatment-related side effects. Future research could explore patient reports of messages received about likely treatment effects both before and during treatment.
DOI: 10.1016/j.ctrv.2018.06.009
ORCID: 0000-0002-1883-4690
Journal: Cancer treatment reviews
PubMed URL: 29936015
Type: Journal Article
Subjects: Cancer
Cancer treatment
Side effects
Appears in Collections:Journal articles

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