Please use this identifier to cite or link to this item:
Title: Attitudes of patients with metastatic cancer towards research biopsies.
Austin Authors: Robinson, Danielle H ;Churilov, Leonid ;Lin, Nancy U;Lim, Elgene;Seah, Davinia
Affiliation: The Florey Institute of Neuroscience and Mental Health, Victoria, Australia
Austin Health, Heidelberg, Victoria, Australia
Dana-Farber Cancer Institute, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
University of New South Wales, Kensington, NSW, Australia
St Vincent's Health, Darlinghurst, NSW, Australia
University of Notre Dame Australia, Darlinghurst, NSW, Australia
Issue Date: Jun-2018 2017-011-06
Publication information: Asia-Pacific journal of clinical oncology 2018; 14(3): 231-238
Abstract: To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial. Patients with metastatic cancer completed a questionnaire that assessed patients' willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as stand-alone procedures (research purposes only biopsy, RPOB) or performed during a clinically indicated biopsy (additional pass biopsy, APB). Factors analyzed included biopsy timing, biopsy site, sociodemographic information and information about prior trial participation. Univariate and multivariable analyses were conducted using random-effects logistic regression. One hundred and sixty-five patients with cancer (40 melanoma, 37 colorectal, 32 breast, 30 lung, 26 prostate) completed the questionnaire. Patients with melanoma demonstrated the greatest willingness to consider a research biopsy compared to patients with other cancer types (P < 0.05). Patients' ethnicity, time since previous biopsies, time since metastatic diagnosis, and previous trial enrolment were all statistically significant for willingness to consider a research biopsy on univariate analysis. When adjusting for statistically significant variables on univariate analysis, the odds of patients considering APBs were 14.6 times greater than RPOBs (P < 0.0001). Patients were also more willing to consider having blood or skin taken for research purposes (P < 0.0001) compared to liver and bone biopsies. Patients with cancer show a greater willingness to consider APBs compared to RPOBs, and biopsies performed at less invasive body sites. There are differences in the attitudes of patients with different cancers towards research biopsies. Further research addressing motivations and barriers to research biopsies should be considered to increase the availability of this important resource.
DOI: 10.1111/ajco.12783
ORCID: 0000-0003-0384-704X
Journal: Asia-Pacific journal of clinical oncology
PubMed URL: 29106060
Type: Journal Article
Subjects: biopsy
patient participation
patient preference
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Feb 3, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.