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Title: Functions of the CXC ligand family in the pancreatic tumor microenvironment.
Austin Authors: Lee, Nien-Hung;Nikfarjam, Mehrdad ;He, Hong 
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-2018
Date: 2018-08-01
Publication information: Pancreatology : official journal of the International Association of Pancreatology (IAP) 2018; 18(7): 705-716
Abstract: Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. This review highlights the roles of selected CXCLs in the interactions between pancreatic tumor and its stroma, and in CSC phenotypes, which can be used to identify potential treatment targets.
DOI: 10.1016/j.pan.2018.07.011
ORCID: 0000-0003-4866-276X
Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP)
PubMed URL: 30078614
Type: Journal Article
Subjects: CXC ligands
Cancer stem cells
Pancreatic cancer
Tumor microenvironment
Appears in Collections:Journal articles

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