Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/18158
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dc.contributor.authorLee, Nien-Hung-
dc.contributor.authorNikfarjam, Mehrdad-
dc.contributor.authorHe, Hong-
dc.date2018-08-01-
dc.date.accessioned2018-08-07T23:03:13Z-
dc.date.available2018-08-07T23:03:13Z-
dc.date.issued2018-08-01-
dc.identifier.citationPancreatology : official journal of the International Association of Pancreatology (IAP) 2018; 18(7): 705-716-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/18158-
dc.description.abstractTherapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. This review highlights the roles of selected CXCLs in the interactions between pancreatic tumor and its stroma, and in CSC phenotypes, which can be used to identify potential treatment targets.-
dc.language.isoeng-
dc.subjectCXC ligands-
dc.subjectCancer stem cells-
dc.subjectChemoresistance-
dc.subjectPancreatic cancer-
dc.subjectTumor microenvironment-
dc.titleFunctions of the CXC ligand family in the pancreatic tumor microenvironment.-
dc.typeJournal Article-
dc.identifier.journaltitlePancreatology : official journal of the International Association of Pancreatology (IAP)-
dc.identifier.affiliationDepartment of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia-
dc.identifier.doi10.1016/j.pan.2018.07.011-
dc.identifier.orcid0000-0003-4866-276X-
dc.identifier.pubmedid30078614-
dc.type.austinJournal Article-
dc.type.austinReview-
local.name.researcherHe, Hong
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptSurgery (University of Melbourne)-
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