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Title: Monoclonal antibodies as immunomodulatory therapy against cancer and autoimmune diseases.
Austin Authors: Hafeez, Umbreen ;Gan, Hui K ;Scott, Andrew M 
Affiliation: Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
School of Cancer Medicine, LaTrobe University, Melbourne, Australia
Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 5-Jun-2018
Date: 2018-06-05
Publication information: Current opinion in pharmacology 2018; 41: 114-121
Abstract: Since Nobel laureate Paul Ehrlich proposed the concept of magic bullet in 1906, Köhler and Milstein discovered Hybridoma technology in 1975, and Greg Winter pioneered the technique to humanize monoclonal antibodies in 1988, monoclonal antibodies have been successfully developed to treat medical illnesses. Monoclonal antibodies are effective treatments for inhibition of alloimmune reactivity, haematological malignancies, solid organ malignancies, viral illnesses and are also used as antiplatelet therapy. Their successful use in cancer and autoimmune diseases in humans have made them one of the fastest growing classes of new drugs approved for these indications in last few decades. This review focuses on the role of monoclonal antibodies as an immunomodulatory therapy against cancer and autoimmune diseases, the strategies used to enhance efficacy, and how resistance mechanisms are being addressed to improve therapeutic outcomes for patients.
DOI: 10.1016/j.coph.2018.05.010
ORCID: 0000-0002-6656-295X
Journal: Current opinion in pharmacology
PubMed URL: 29883853
Type: Journal Article
Appears in Collections:Journal articles

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