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Title: Pilot validation of an individualised pharmacokinetic algorithm for protamine dosing after systemic heparinisation for cardiopulmonary bypass.
Austin Authors: Miles, Lachlan F ;Marchiori, Paolo;Falter, Florian
Affiliation: Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
Cambridge Perfusion LLC, Cambridge, UK
Department of Anaesthesia and Intensive Care, Papworth Hospital NHS Foundation Trust, UK
Issue Date: Sep-2017 2017-03-01
Publication information: Perfusion 2017; 32(6): 481-488
Abstract: This manuscript represents a pilot study assessing the feasibility of a single-compartment, individualised, pharmacokinetic algorithm for protamine dosing after cardiopulmonary bypass. A pilot cohort study in a specialist NHS cardiothoracic hospital targeting patients undergoing elective cardiac surgery using cardiopulmonary bypass. Patients received protamine doses according to a pharmacokinetic algorithm (n = 30) or using an empirical, fixed-dose model (n = 30). Categorical differences between the groups were evaluated using the Chi-squared test or Fisher's exact test. Continuous data was analysed using a paired Student's t-test for parametric data and the paired samples Wilcoxon test for non-parametric data. Patients who had protamine dosing according to the algorithm demonstrated a lower protamine requirement post-bypass relative to empirical management as measured by absolute dose (243 ± 49mg vs. 305 ± 34.7mg; p<0.001) and the heparin to protamine ratio (0.79 ± 0.12 vs. 1.1 ± 0.15; p<0.001). There was no difference in the pre- to post-bypass activated clotting time (ACT) ratio (1.05 ± 0.12 vs. 1.02 ± 0.15; p=0.9). Patients who received protamine according to the algorithm had no significant difference in transfusion requirement (13.3% vs. 30.0%; p=0.21). This study showed that an individualized pharmacokinetic algorithm for the reversal of heparin after cardiopulmonary bypass is feasible in comparison with a fixed dosing strategy and may reduce the protamine requirement following on-pump cardiac surgery.
DOI: 10.1177/0267659117695881
PubMed URL: 28820026
Type: Journal Article
Subjects: algorithms
cardiopulmonary bypass
heparin antagonists
Appears in Collections:Journal articles

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