Prospective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy.

2018-09

Chao, Michael

Ho, Huong

Chan, Yee

Tan, Alwin

Pham, Trung

Bolton, Damien M

Troy, Andrew J

Temelcos, Catherine

Sengupta, Shomik

McMillan, Kevin

Cham, Chee Wee

Liu, Madalena

Ding, Wei

Subramanian, Brindha

Wasiak, Jason

Lim Joon, Daryl

Spencer, Sandra

Lawrentschuk, Nathan

#PCSM

#ProstateCancer

hydrogel spacer

intensity-modulated RT

volumetric-modulated arc RT

Journal Article

0000-0002-8212-4220

0000-0003-3357-1216

0000-0001-9681-2174

0000-0001-8553-5618

0000-0002-5145-6783

#PLACEHOLDER_PARENT_METADATA_VALUE#

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#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

#PLACEHOLDER_PARENT_METADATA_VALUE#

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10.1111/bju.14192

To report on the dosimetric benefits and late toxicity outcomes after injection of hydrogel spacer (HS) between the prostate and rectum for patients treated with prostate radiotherapy (RT). In all, 76 patients with a clinical stage of T1-T3a prostate cancer underwent general anaesthesia for fiducial marker insertion plus injection of the HS into the perirectal space before intensity-modulated RT (IMRT) or volumetric-modulated arc RT (VMAT). HS safety, dosimetric benefits, and the immediate- to long-term effects of gastrointestinal (GI) toxicity were assessed. There were no postoperative complications reported. The mean (range) prostate size was 66.0 (25.0-187.0) mm. Rectal dose volume parameters were observed and the volume of rectum receiving 70 Gy (rV70 ), 75 Gy (rV75 ) and 78 Gy (rV78 ) was 7.8%, 3.6% and 0.4%, respectively. In all, 21% of patients (16/76) developed acute Grade 1 GI toxicities, but all were resolved completely by 3 months after treatment; whilst, 3% of patients (2/76) developed late Grade 1 GI toxicities. No patients had acute or late Grade ≥2 GI toxicities. Injection of HS resulted in a reduction of irradiated rectal dose volumes along with minimal GI toxicities, irrespective of prostate size.

link

BJU International 2018; 122(3): 427-433

BJU International