Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17928
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dc.contributor.authorChao, Michael-
dc.contributor.authorHo, Huong-
dc.contributor.authorChan, Yee-
dc.contributor.authorTan, Alwin-
dc.contributor.authorPham, Trung-
dc.contributor.authorBolton, Damien M-
dc.contributor.authorTroy, Andrew J-
dc.contributor.authorTemelcos, Catherine-
dc.contributor.authorSengupta, Shomik-
dc.contributor.authorMcMillan, Kevin-
dc.contributor.authorCham, Chee Wee-
dc.contributor.authorLiu, Madalena-
dc.contributor.authorDing, Wei-
dc.contributor.authorSubramanian, Brindha-
dc.contributor.authorWasiak, Jason-
dc.contributor.authorLim Joon, Daryl-
dc.contributor.authorSpencer, Sandra-
dc.contributor.authorLawrentschuk, Nathan-
dc.date2018-03-09-
dc.date.accessioned2018-06-21T05:31:11Z-
dc.date.available2018-06-21T05:31:11Z-
dc.date.issued2018-09-
dc.identifier.citationBJU International 2018; 122(3): 427-433en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17928-
dc.description.abstractTo report on the dosimetric benefits and late toxicity outcomes after injection of hydrogel spacer (HS) between the prostate and rectum for patients treated with prostate radiotherapy (RT). In all, 76 patients with a clinical stage of T1-T3a prostate cancer underwent general anaesthesia for fiducial marker insertion plus injection of the HS into the perirectal space before intensity-modulated RT (IMRT) or volumetric-modulated arc RT (VMAT). HS safety, dosimetric benefits, and the immediate- to long-term effects of gastrointestinal (GI) toxicity were assessed. There were no postoperative complications reported. The mean (range) prostate size was 66.0 (25.0-187.0) mm. Rectal dose volume parameters were observed and the volume of rectum receiving 70 Gy (rV70 ), 75 Gy (rV75 ) and 78 Gy (rV78 ) was 7.8%, 3.6% and 0.4%, respectively. In all, 21% of patients (16/76) developed acute Grade 1 GI toxicities, but all were resolved completely by 3 months after treatment; whilst, 3% of patients (2/76) developed late Grade 1 GI toxicities. No patients had acute or late Grade ≥2 GI toxicities. Injection of HS resulted in a reduction of irradiated rectal dose volumes along with minimal GI toxicities, irrespective of prostate size.en_US
dc.language.isoeng-
dc.subject#PCSMen_US
dc.subject#ProstateCanceren_US
dc.subjecthydrogel spaceren_US
dc.subjectintensity-modulated RTen_US
dc.subjectvolumetric-modulated arc RTen_US
dc.titleProspective analysis of hydrogel spacer for patients with prostate cancer undergoing radiotherapy.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBJU Internationalen_US
dc.identifier.affiliationGenesis Cancer Care Victoria, Ringwood East, Victoria, Australiaen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.affiliationMelbourne University; Eastern Health Clinical School, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.affiliationSt Vincent's Hospital, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationThe Valley Private Hospital, Mulgrave, Victoria, Australiaen_US
dc.identifier.affiliationRingwood Private Hospital, Ringwood East, Victoria, Australiaen_US
dc.identifier.affiliationThe Bays Hospital, Mornington, Victoria, Australiaen_US
dc.identifier.affiliationUniversity of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.doi10.1111/bju.14192en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-8212-4220en_US
dc.identifier.orcid0000-0003-3357-1216en_US
dc.identifier.orcid0000-0001-9681-2174en_US
dc.identifier.orcid0000-0001-8553-5618en_US
dc.identifier.orcid0000-0002-5145-6783en_US
dc.identifier.pubmedid29520983-
dc.type.austinJournal Article-
local.name.researcherBolton, Damien M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
crisitem.author.deptSurgery-
crisitem.author.deptUrology-
crisitem.author.deptRadiation Oncology-
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