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Title: Standardized Measurement of Sensorimotor Recovery in Stroke Trials: Consensus-Based Core Recommendations from the Stroke Recovery and Rehabilitation Roundtable.
Austin Authors: Kwakkel, Gert;Lannin, Natasha A;Borschmann, Karen ;English, Coralie;Ali, Myzoon;Churilov, Leonid ;Saposnik, Gustavo;Winstein, Carolee;van Wegen, Erwin E H;Wolf, Steven L;Krakauer, John W;Bernhardt, Julie
Affiliation: Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, USA
School of Allied Health, La Trobe University, Melbourne, Australia
Department of Occupational Therapy, Alfred Health, Melbourne, Australia
Stroke Division, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Australia
NHMRC Centre of Research Excellence Stroke Rehabilitation and Brain Recovery, Melbourne, Australia
University of Newcastle School of Health Sciences and Priority Research Centre for Stroke and Brain Injury, Hunter Medical Research Institute, Australia
Nursing, Midwifery and Allied Health Professions (NMAHP) Research Unit, Glasgow Caledonian University, UK
Institutes of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
Stroke Outcomes Research & Center for Virtual Reality Studies ( )
Department of Medicine (Neurology), Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Canada
Division Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry and Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam Neuroscience, VU University Medical Center Amsterdam, The Netherlands
Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta; VA Center for Visual and Neurocognitive Rehabilitation, Atlanta, GA, USA
Departments of Neurology, Neuroscience, and Physical Medicine & Rehabilitation, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Issue Date: Sep-2017
Publication information: Neurorehabilitation and neural repair 2017; 31(9): 784-792
Abstract: Finding, testing and demonstrating efficacy of new treatments for stroke recovery is a multifaceted challenge. We believe that to advance the field, neurorehabilitation trials need a conceptually rigorous starting framework. An essential first step is to agree on definitions of sensorimotor recovery and on measures consistent with these definitions. Such standardization would allow pooling of participant data across studies and institutions aiding meta-analyses of completed trials, more detailed exploration of recovery profiles of our patients and the generation of new hypotheses. Here, we present the results of a consensus meeting about measurement standards and patient characteristics that we suggest should be collected in all future stroke recovery trials. Recommendations are made considering time post stroke and are aligned with the international classification of functioning and disability. A strong case is made for addition of kinematic and kinetic movement quantification. Further work is being undertaken by our group to form consensus on clinical predictors and pre-stroke clinical data that should be collected, as well as recommendations for additional outcome measurement tools. To improve stroke recovery trials, we urge the research community to consider adopting our recommendations in their trial design.
DOI: 10.1177/1545968317732662
ORCID: 0000-0003-2543-8722
Journal: Neurorehabilitation and neural repair
PubMed URL: 28934918
Type: Journal Article
Subjects: Clinical research
Appears in Collections:Journal articles

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