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Title: Trajectories of irregular word reading ability as a proxy for premorbid intelligence in Alzheimer's disease, mild cognitive impairment, and healthy aging: A longitudinal study.
Austin Authors: Weinborn, Michael;Bucks, Romola S;Sohrabi, Hamid R;Rainey-Smith, Stephanie R;Brown, Belinda M;Gardener, Samantha L;Gozt, Aleksandra;Christensen, Daniel;Savage, Greg;Laws, Simon M;Taddei, Kevin;Maruff, Paul;Robertson, Joanne S;Ellis, Kathryn A;Ames, David;Masters, Colin L ;Rowe, Christopher C ;Martins, Ralph N
Affiliation: School of Psychological Science, University of Western Australia
School of Medical and Health Sciences, Edith Cowan University
Australian Alzheimer's Research Foundation
Telethon Kids Institute
ARC Centre of Excellence in Cognition and Its Disorders, Department of Psychology, Macquarie University
CogState, Ltd
Neurodegeneration Division, The Florey Institute, The University of Melbourne
Neurodegeneration Division, The Florey Institute, Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne
National Ageing Research Institute
Department of Molecular Imaging, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, The University of Melbourne
Issue Date: Oct-2018 2018-05-21
Publication information: Psychological assessment 2018; 30(10): 1308-1316
Abstract: The ability to read irregularly spelled words is commonly used to estimate premorbid intelligence, as this ability has been thought to be resistant to early effects of neurodegenerative disorders. However, studies evaluating decline of this skill in Alzheimer's disease (AD) have produced conflicting results. Irregular word reading was assessed three times over 36 months in a large (N = 995) sample, including healthy control, AD, and Mild Cognitive Impairment (MCI) groups. At baseline, MCI and AD groups read correctly an average of 3.01 and 7.39 fewer words, respectively, than healthy controls. The MCI group's performance remained stable during the study, but the AD group declined. Importantly, the observed decline was likely an underestimate, as significant numbers of the AD participants (42.6%) could not complete the task at follow-up. Use of alternate (e.g., demographics-based) methods is advised to augment or replace word pronunciation in estimating premorbid intelligence in individuals with even mild AD. (PsycINFO Database Record
DOI: 10.1037/pas0000565
ORCID: 0000-0001-7094-9930
PubMed URL: 29781669
Type: Journal Article
Appears in Collections:Journal articles

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