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https://ahro.austin.org.au/austinjspui/handle/1/17385| Title: | Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. | Austin Authors: | Mattsson, Niklas;Groot, Colin;Jansen, Willemijn J;Landau, Susan;Villemagne, Victor;Engelborghs, Sebastiaan;Mintun, Mark;Lleo, Alberto;Molinuevo, José Luis;Jagust, William;Frisoni, Giovanni B;Ivanoiu, Adrian;Chételat, Gaël;Resende de Oliveira, Catarina;Rodrigue, Karen M;Kornhuber, Johannes;Wallin, Anders;Klimkowicz-Mrowiec, Aleksandra;Kandimella, Ramesh;Popp, Julius;Aalten, Pauline P;Aarsland, Dag;Alcolea, Daniel;Almdahl, Ina S;Baldeiras, Inês;van Buchem, Mark A;Cavedo, Enrica;Chen, Kewei;Cohen, Ann D;Förster, Stefan;Fortea, Juan;Frederiksen, Kristian S;Freund-Levi, Yvonne;Gill, Kiran Dip;Gkatzima, Olymbia;Grimmer, Timo;Hampel, Harald;Herukka, Sanna-Kaisa;Johannsen, Peter;van Laere, Koen;de Leon, Mony;Maier, Wolfgang;Marcusson, Jan;Meulenbroek, Olga;Møllergård, Hanne M;Morris, John C;Mroczko, Barbara;Nordlund, Arto;Prabhakar, Sudesh;Peters, Oliver;Rami, Lorena;Rodríguez-Rodríguez, Eloy;Roe, Catherine M;Rüther, Eckart;Santana, Isabel;Schröder, Johannes;Seo, Sang W;Soininen, Hilkka;Spiru, Luiza;Stomrud, Erik;Struyfs, Hanne;Teunissen, Charlotte E;Verhey, Frans R J;Vos, Stephanie J B;van Waalwijk van Doorn, Linda J C;Waldemar, Gunhild;Wallin, Åsa K;Wiltfang, Jens;Vandenberghe, Rik;Brooks, David J;Fladby, Tormod;Rowe, Christopher C ;Drzezga, Alexander;Verbeek, Marcel M;Sarazin, Marie;Wolk, David A;Fleisher, Adam S;Klunk, William E;Na, Duk L;Sánchez-Juan, Pascual;Lee, Dong Young;Nordberg, Agneta;Tsolaki, Magda;Camus, Vincent;Rinne, Juha O;Fagan, Anne M;Zetterberg, Henrik;Blennow, Kaj;Rabinovici, Gil D;Hansson, Oskar;van Berckel, Bart N M;van der Flier, Wiesje M;Scheltens, Philip;Visser, Pieter Jelle;Ossenkoppele, Rik | Affiliation: | Department of Nuclear Medicine, University of Cologne, Cologne, Germany Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK UK Dementia Research Institute, London, UK Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia Reference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium Avid Radiopharmaceuticals, Philadelphia, PA, USA Neurology Department, Hospital de Sant Pau, Barcelona, Spain Alzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain Memory Clinic and LANVIE- Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy Memory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France Center for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Portugal Center for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA Department of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden Jagiellonian University College of Medicine, Krakow, Poland Postgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India Department of Psychiatry, Service of Old Age Psychiatry, University Hospital of LaUSAnne, LaUSAnne, Switzerland Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway Department of Neurology, Akershus University Hospital, Lørenskog, Norway Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands AXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France Banner Alzheimer's Institute, Phoenix, AZ, USA University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA Department of Nuclear Medicine, Technische Universitaet München, Munich, Germany Danish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany Department of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland Memory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark Department of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium School of Medicine, Center for Brain Health, New York University, New York, NY, USA Department of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Geriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden Department of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands Knight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA Department of Neurodegeneration Diagnostics, Leading National Research Centre in Białystok (KNOW), Medical University of Białystok, Białystok, Poland Department of Neurology, Research Block-A, Chandigarh, India Department of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany Neurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany Sektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea Department of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands Laboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium Division of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA Eli Lilly, Indianapolis, IN, USA Department of Neurosciences, University of California, San Diego, CA, USA Department of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea Department NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden CHRU de Tours, CIC INSERM 1415, INSERM U930, Université François Rabelais de Tours, Tours, France Turku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden Sweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands |
Issue Date: | 2018 | Date: | 2018-03-27 | Publication information: | Alzheimer's & dementia 2018; 14(7): 913-924 | Abstract: | Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location. The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education. The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/17385 | DOI: | 10.1016/j.jalz.2018.02.009 | ORCID: | 0000-0003-3910-2453 | Journal: | Alzheimer's & dementia | PubMed URL: | 29601787 | Type: | Journal Article | Subjects: | APOE Age Alzheimer's disease Amyloid CSF Education Geographical location Mild cognitive impairment PET Prevalence Sex Subjective cognitive decline |
| Appears in Collections: | Journal articles |
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